Protective Effect of Cumin and Coriander on Profenofos

Profenofos [0-4-bromo-2-chlorophenyl -0-ethyl S-propyi phosphorothioate] is a broad spectrum organophosphate insecticide and acaricide. Its main physiological effect is the inhibition of cholinesterase activity in insects. In the present study Profenofos @ 25 mg/kg b.w was administered to the Swiss albino mice for 4 weeks to observe the Profenofos induced hepatotoxicity. Upon this group Cuminum cyminum (Cumin) and Coriandrum sativum (Coriander) were administered for 4 weeks to observe its antidote effect. The study through various paramaters shows that Cumin and Coriander play vital role to combat the Profenofos induced hepatotoxicity thus showing its protective effect.

Autorentext

Rashmi Singh, M.Tech.(VLSI Design & CAD), Thapar University, Lecturer, Electronics and Communication Department, Swami Devi Dyal Institute of Engineering and Technology, Haryana, India.