Protein Folding in Silico

Informationen zum Autor Professor Irena Roterman-Konieczna completed her PhD at the Nicolaus Copernicus Medical Academy Krakow, Poland and undertook her postdoctoral studies at Cornell University, USA. She is the director of the Department of Bioinformatics and Telemedicine at Jagiellonian University Medical College, Poland. Her fields of interest are protein structure, folding simulation as well as systems biology. She is the author of "Protein Folding in Silico", published by Woodhead Publishing in 2012., and "From Globular Proteins to Amyloids" published by Elsevier in 2020. She is the Chief Editor of the journal Bio-Algorithms and Med-Systems (de Gruyter). Zusammenfassung Protein folding in silico is broad in scope - starting with ab initio models and attempting to construct a mechanistic model on the basis of their predictions.

Autorentext
Professor Irena Roterman-Konieczna completed her PhD at the Nicolaus Copernicus Medical Academy Krakow, Poland and undertook her postdoctoral studies at Cornell University, USA. She is the director of the Department of Bioinformatics and Telemedicine at Jagiellonian University Medical College, Poland. Her fields of interest are protein structure, folding simulation as well as systems biology. She is the author of "Protein Folding in Silico", published by Woodhead Publishing in 2012., and "From Globular Proteins to Amyloids" published by Elsevier in 2020. She is the Chief Editor of the journal Bio-Algorithms and Med-Systems (de Gruyter).

Klappentext

Protein folding in silico is broad in scope - starting with ab initio models and attempting to construct a mechanistic model on the basis of their predictions.

Inhalt

Early Stage intermediate; Late stage intermediate; Structural information involved in the interpretation of the stepwise protein folding process; Divergence entropy characterizing the internal force field in proteins: Ligand binding site recognition; The "fuzzy oil drop" model to identify the complexation area in protein homodimers; Simulation of the polypeptide chain folding process using "fuzzy oil drop" model; Misfolded proteins; Short description of other selected ab initio methods for protein structure prediction.