Protein Tyrosine Phosphatases in Cancer

This book aims to bridge the gap in understanding how protein-tyrosine phosphatases (PTPs), which carry out the reverse reaction of tyrosine phosphorylation, feature in cancer cell biology. The expertly authored chapters will first review the general features of the PTP superfamily, including their overall structure and enzymological properties; use selected examples of individual PTP superfamily members, to illustrate emerging data on the role of PTPs in cancer; and will review the current status of PTP-based drug development efforts. *

• Protein Tyrosine Phosphatases in Cancer, from renowned researchers Benjamin Neel ** and Nicholas Tonks, is invaluable reading for researchers in oncology, stem cell signaling,and biochemistry.

  Discusses the current status of PTP-based therapeutics Examines phosphatase-independent roles for PTEN in Cancer Explores dual specificity phosphatases in cancer

  Autorentext
  Dr. Neel earned his PhD in Viral Oncology from The Rockefeller University and his MD degree from Cornell University Medical School. After completing residency and post-doctoral training at Harvard institutions, he was appointed Assistant Professor of Medicine at Harvard Medical School (HMS), and began his own independent research laboratory in the Molecular Medicine Unit at Beth Israel Hospital in Boston, now known as Beth Israel Deaconess Medical Center (BIDMC). He also served as the Director of the Cancer Biology Program and as Deputy Director for Basic Research, Hematology Division at BIDMC. Currently, Dr. Neel is Director of the Laura and Isaac Perlmutter Cancer Center at New York University Langone Medical Center, as well as a Professor in the Department of Medicine at NYU.

  Dr Neel is the author of over 160 original papers and 25 invited reviews. He was the inaugural recipient of the Gertrude Elion Awardof the American Association for Cancer Research and holds an NIH MERIT award. His current scientific interests focus on cell signaling, with a particular emphasis on protein-tyrosine phosphatases (PTPs), as well as tumor stem cell signaling and the roles of Shp2 and its binding proteins in several human diseases.
  Dr Tonks was educated at Oxford University and the University of Dundee, where he earned his PhD. He subsequently conducted postdoctoral studies at the University of Washington with Edmond H. Fischer, and moved to the Cold Spring Harbor Laboratory, where he was promoted to his current position of full Professor.

  Dr. Tonks has published over 180 papers in the field and has been granted 10 patents. His research has been recognized by several awards, including a MERIT Award from the NIH and the Colworth Medal (British Biochemical Society). He is a Fellow of the Royal Society and was a PewScholar in the Biomedical Sciences. Dr. Tonks' research focuses on functional analysis of members of the PTP family, using various approaches including RNA interference, in cell and animal models of disease.

Inhalt
1 Introduction to the PTP Superfamily.- 2 Receptor PTPs in Cancer.- 3 Non-Receptor PTPs in Cancer.- 4 HP2.- 5 C-PTP.- 6 PTP1B.- 7 PTP-PEST.- 8 Dual Specificity Phosphatases in Cancer.- 9 Phosphatase-dependent roles for PTEN in Cancer.- 10 Phosphatase-independent roles for PTEN in Cancer.- 11 PRL family members in Cancer.- 12 Cdc25 family.- 13 PTPs, metabolism and cancer.- 14 PTPs, metabolism and cancer.- 15 Current status of PTP-based therapeutics.- 16 Summary and Perspective.