Pyrazoles and Pyrrolo[3,2-c]pyridines as Anticancer Agents

In the present investigation, novel pyrazoles and pyrrolo[3,2-c]pyridines have been designed as potential antiproliferative agents against different types of cancer. Their antiproliferative activities were examined against 61 cancer cell lines of 9 different cancer types. Biological investigation of representative target compounds at molecular level was conducted in order to investigate the possible mechanism(s) of antiproliferative activity of our target compounds. In addition, molecular modeling study was carried out. Some compounds showed broad-spectrum antiproliferative activity, while others demonstrated selectivity over certain types of cancer. Our research led to discovery a selective FMS kinase inhibitor, multiple-kinase inhibitor, ERK kinase inhibitors, and dual ERK/COX-2 inhibitors. This work led to development of novel lead anticancer agents, which can be utilized for future development of potential anticancer agents.

Autorentext

Mohammed I. El-Gamal, Ph.D., got his Ph.D. degree in medicinal chemistry from University of Science and Technology (UST) and Korea Institute of Science andTechnology (KIST), Republic of Korea, in 2012. After graduation, he held the position of star postdoctoral fellow at KIST. He is the author of many articles published in reputed journals.