QSAR studies on Topoisomerase-II inhibitors

The objective of drug discovery phase is to synthesize lead compounds, new analogs with improved potency, reduced off target activities, and physiochemical/metabolic properties suggestive of reasonable in vivo pharmacokinetics. This optimization is accomplished through empirical modification of the hit structure and/or by employing structure-based design if structural information about the target is available. The goal of present work is to design drug with minimum side effect and maximum potency. 2D QSAR is planned using Multiple Linear Regression Analysis, for achieving the goal, which can help in recognizing the important descriptor that can help in increasing the potency of anticancer drugs.

Autorentext

Dr. Meenakshi Sharma is perusing PhD. in Department of Community Medicine, School of Public health, PGIMER, Chandigarh, India. Before that she has done Masters in Public Health (MPH) for the same Institute. She has got many research papers and chapters published in indexed and non indexed journals to her credit.