Quantitative Trait Loci (QTL)

This Methods in Molecular Biology(TM) volume offers techniques for the entire process of quantitative train loci experiments: the mapping populations, identifying quantitative trait loci, extending the power of quantitative trait locus analysis and case studies.

Over the last two decades advances in genotyping technology, and the development of quantitative genetic analytical techniques have made it possible to dissect complex traits and link quantitative variation in traits to allelic variation on chromosomes or quantitative trait loci (QTLs). In Quantitative Trait Loci (QTLs):Methods and Protocols , expert researchers in the field detail methods and techniques that focus on specific components of the entire process of quantitative train loci experiments. These include methods and techniques for the mapping populations, identifying quantitative trait loci, extending the power of quantitative trait locus analysis, and case studies. Written in the highly successful Methods in Molecular Biology ™ series format, the chapters include the kind of detailed description and implementation advice that is crucial for getting optimal results in the laboratory.

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Thorough and intuitive, Quantitative Trait Loci (QTLs):Methods and Protocols aids scientists in the further study of the links between phenotypic and genotypic variation in fields from medicine to agriculture, from molecular biology to evolution to ecology.

A practical resource for researchers interested in link between phenotypic and genotypic variation Provides step-by-step detail essentail for reproducible results Contains key notes and implementation advice from the experts

Inhalt

Backcross Populations and Near Isogenic Lines.-F 2 Designs for QTL Analysis.-Design and Construction of Recombinant Inbred Lines.-Two Flavors of Bulk Segregant Analysis in Yeast.-Selecting Markers and Evaluating Coverage.-Composite Interval Mapping and Multiple Interval Mapping: Procedures and Guidelines for Using Windows QTL Cartographer.-Design Database for Quantitative Trait Loci (QTL) Data Warehouse, Data Mining and Meta Analysis.-Meta-Analysis of QTL Mapping Experiments.-Using eQTLs to Reconstruct Gene Regulatory Networks.-Estimation and Interpretation of Genetic Effects with Epistasis using the NOIA Model.-Identifying QTL for Multiple Complex Traits in Experimental Crosses.-Functional Mapping of Developmental ProcessesTheory, Applications and Prospects.-Statistical Models for Genetic Mapping in Polyploids: Challenges and Opportunities.-eQTL.-Genetic Mapping of Quantitative Trait Loci for Disease-Related Phenotypes.-Quantitative Trait Locus Analysis in Haplodiploid Hymenoptera.