Rapid acting fentanyl formulations in breakthrough pain in cancer.

A rational and transparent method, System of Objectified Judgement Analysis (SOJA), for drug selection is described for selection of rapid acting fentanyl formulations for breakthrough pain in cancer-related pain. The relevant selection criteria for a group of drugs are defined and judged by a panel of experts. The more important that a selection criterion is considered, the higher the relative weight that is given to that criterion. The ideal properties for each selection criterion are determined and each drug is scored as a percentage of the relative weight for all selection criteria. Selection criteria (relative weight) were: number of available strengths (60), variability in rate of absorption (50), interactions (50), clinical efficacy (350), side-effects (150), ease of administration (140) and documentation (200). The sublingual fentanyl orally disintegrating tablet (Abstral) showed the highest overall score, followed by the nasal sprays (Instanyl and PecFent). These are the most attractive formulations from a formulary perspective.

Autorentext

Robert Janknegt arbeitet als Krankenhausapotheker und klinischer Pharmakologe am Zuyderland Medical Centre in Sittard-Geleen, Niederlande. Sein Hauptforschungsprojekt ist die rationale Entscheidungsfindung bei der Auswahl von Arzneimitteln aus der Perspektive der Arzneimittelliste mit Hilfe eines interaktiven Matrixmodells.