Recent Progress in the Chemical Synthesis of Antibiotics and Related Microbial Products Vol. 2

The book is a valuable source of information on synthetic strategies for chemical compounds exhibiting antibiotic acitvity. Twenty leading international research groups from academic and industrial laboratories have contributed. The book is of particular interest to the Pharmaceutical industry and to academic Organic Chemistry departments.

Klappentext

Eighteen leading research groups from academic and industrial pharmaceutic laboratories have contributed to this unique compilation on the chemical synthesis of various classes of antibiotics and antibiotic microbial products. The book will be valuable reading for scientists and researchers involved in the development of new substances and drugs with antibiotic activity.

Inhalt
Cyclization Methods Related to the Synthesis of Macrolide Antibiotics.- Progress in the Total Synthesis of Spirotetronic Acid Macrolide Antibiotics.- Convergent Stereospecific Total Synthesis of Monocillin I and Monorden (or Radicicol).- Recent Progress in the Chemical Modification of Erythromycin.- Chemistry of FK - 506.- The Enediyne Antibiotics Calicheamicin ?1I, Esperamicin-Ar and Dynemicin-A: Physicochemical and Biological Properties-Partial and Total Synthesis.- Synthesis and Chemistry of Neocarzinostatin Analogs.- Synthesis of Nogalamycin and Related Substances.- Total Synthesis of Aryl C-Glycoside Antibiotics.- Total Synthesis of the Antifungal Antibiotic Ambruticin.- Synthetic Approaches to Methylenomycin B and Analogs.- The Orthosomycin Antibiotics.- ? -Unsubstituted ? -Lactams as Synthons for Antibiotics.- Chemistry and Synthesis of some Novel ? -Lactam Antibiotics and ? -Lactamase Inhibitors.- Recent Advances in the Chemistry and Biochemistry of ? -Lactams as ? -Lactamase Inhibitors.- Chemistry of Biologically Important Hydroxylated Indolizidines Synthesis of Swainsonine, Castanospermine and Slaframine.- The Chemistry and Total Synthesis of Mevinolin and Related Compounds.- Synthetic Efforts Towards Cerulenin and Tetrahydrocerulenin.