Recent Progress in the Chemical Synthesis of Antibiotics

The book is a valuable source of information on synthetic strategies for chemical compounds exhibiting antibiotic activity. Twenty leading international research groups from academic and industrial laboratories have contributed. The book is of particular interest to the pharmaceutical industry and to academic organic chemistry departments.

Inhalt
Total Synthesis of Macrolide Antibiotics.- Structural Modification of Macrolide Antibiotics.- Avermectins and Milbemycins.- Ansamacrolides.- Polyene Macrolides: Stereostructural Elucidation and Synthetic Studies of a Few Members.- The Chemistry of Pristinamycins.- Recent Advances in the Chemistry of Quinolones.- Actinobolin and Bactobolin: Chemical Aspects and Syntheses.- Nucleosides: Potential Drugs for AIDS Therapy.- Total Synthesis of Lincomycin and Related Chemistry.- Synthetic Study on Man-Made Bleomycins Based on the Anticancer Mechanism of Natural Bleomycins.- Synthesis of Mitomycins.- Total Synthesis of Polyether Antibiotics.- Synthesis of Anthracyclines Related to Daunomycin.- Synthesis of Polynuclear Aromatic Antibiotics.- Synthetic Aspects of Monocyclic ?-Lactam Antibiotics.- Recent Advances in the Synthesis of PS-5 and PS-6 Antibiotics and Related Carbapenem Compounds.- Synthesis of Penems.- 1-Oxacephem Antibiotics.- Non-?-Lactam Analogs of Penicillins and Cephalosporins.