Recent Trends in Cancer Biology: Spotlight on Signaling Cascades and microRNAs

Cancer is a multifaceted disease and overwhelmingly increasing experimental evidence has helped us to develop a deeper understanding of the role of signal transduction cascades in cancer development and progression. Tissue microarrays and next generation sequencing technologies have assisted us to gather missing pieces of jigsaw puzzle and we now know that deregulation of spatio-temporally controlled signaling cascades play fundamental role in metastasis and resistance against wide ranging therapeutics.
This book offers a balanced overview of the rapidly emerging cutting edge research in molecular oncology and good source of knowledge for established oncologists, basic and medical students and pharmaceutical industry associated R&D departments.

Features cutting-edge coverage and translational perspective; Provides mechanistic insights and most recent 'bench to bedside and back' breakthroughs; Different chapters of the book are written by an international panel of researchers, specialists and practitioners in the field; This book presents a much-needed conceptual synthesis of the rapidly evolving field of molecular oncology;

Autorentext
Sundas Fayyaz is working as a Scientist in research laboratory of Rashid Latif Medical College (RLMC). Her expertise lies in cancer genetics and therapeutics.
Ammad Ahmad Farooqi is currently a Senior Scientist at the Institute of Biomedical and Genetic Engineering (IBGE), in Islamabad, Pakistan. His area of research is tightly focused on cancer genetics and therapeutics.

Inhalt

From Endometriosis to Cancer: Spotlight on Intracellular Signaling Cascades and MicroRNAs.- Tyrosine kinases, microRNAs, epigenetics: new insights in the mechanisms of leukemogenesis.- The emerging role of exosomes in cancer progression and their potential as therapy targets.- Tranquilizing and Awakening ATM to Promote Killing of Cancer Cells.- The Role of GPER Signaling in Carcinogenesis: a Focus on Prostate Cancer.- Bone Cancer: Dysregulation of Signaling Cascades by microRNAs.- The roles of miR-25 and its targeted genes in human cancer. Notch Signaling in Lung Cancer Initiation and Development.- TGF-/Smad signalling pathway in cancer.- Natural Agents Mediated Regulation of microRNAs: Do We Need Skilled Archers to Hit the Bullseye.- Sebaceous Carcinoma of the Eyelid.- Current knowledge of miRNAs as biomarkers in Breast Cancer.- Signaling Landscape of AML: The Story So Far.- When the molecules start playing chess, or how microRNAs acquire dualistic activity during cancer progression.- The Crosstalk Between miRNAs and Autophagy in Cancer Progression.- Role of CEACAM in Different Cancers.- Index.