Reelin Glycoprotein

Reelin glycoprotein is a serine protease with important roles in embryogenesis and during adult life. Reelin mutations or deficiency of the protein product could cause abnormal cortical development and reelin signaling impairment in brain. Reelin abnormalities in several neurospychiatric disorders, such as autism, schizophrenia, mood disorders and lissencephaly, may provide mechanistic explanations for etiologies of these disorders. There is also emerging data indicating the feasibility of using various medications (valproic acid, olanzapine) to increase mRNA/protein levels for reelin and/or gene therapy to prevent or treat reelin deficiencies observed in the above-mentioned disorders.

This comprehensive and integrative book examines the role that reelin plays in the etiology of various neuropsychiatric disorders, including schizophrenia and autism.

Provides an unprecedented analysis of this emerging and novel protein by examining evidence from genetic, neuroanatomic, biochemical, and behavioral studies

Klappentext

Reelin glycoprotein is a major secretory protein with important roles in embryogenesis and during adult life. Reelin gene mutations or deficiency of the protein product cause abnormal cortical development and reelin signaling impairment in brain. Since the first discovery of the reelin mutant mouse in 1951 by Falconer, and later discovery of the gene for reelin in 1995, there has been an explosion of new knowledge about this important molecule. Reelin Glycoprotein: Structure, Biology and Roles in Health and Disease, written by an international panel of experts, summarizes the state of the knowledge on various aspects of reelin. Topics include the reelin gene and its receptors, downstream effector molecules in reelin signaling cascade, chemistry and structure of reelin, comparative anatomy of reelin, presence of reelin in various body tissues, reelin mutations, and abnormalities of reelin production in neuropsychiatric disorders and cancer. This book will serve as a foundation for analysis of this emerging novel protein for all neuroscientists and clinicians.

Inhalt
The Reelin Gene and Its Functions in Brain Development.- Apolipoprotein E Receptor 2 and Very-Low-Density Lipoprotein Receptor: An Overview.- Chemistry of Reelin.- The C-Terminal Region of Reelin: Structure and Function.- Crystal Structure of Reelin Repeats.- Comparative Anatomy and Evolutionary Roles of Reelin.- Reelin/Dab1 Signaling in the Developing Cerebral Cortex.- Ultrastructural Localization of Reelin.- Reelin and Cyclin-Dependent Kinase 5.- Reelin and the Cerebellum.- Reelin and Radial Glial Cells.- Reelin and Cognition.- Protein Kinases and Signaling Pathways that Are Activated by Reelin.- The Relationship of Oxytocin and Reelin in the Brain.- Reelin and Thyroid Hormone.- A Tale of Two Genes: Reelin and BDNF.- Reelin, Liver, and Lymphatics.- Reelin and Cajal-Retzius Cells.- Reelin and Odontogenesis.- Homozygous and Heterozygous Reeler Mouse Mutants.- Reelin and Lissencephaly.- The Role of Reelin in Etiology and Treatment of Psychiatric Disorders.- Reelin Downregulation as a Prospective Treatment Target for GABAergic Dysfunction in Schizophrenia.- Epigenetic Modulation of Reelin Function in Schizophrenia and Bipolar Disorder.- Reelin Gene Polymorphisms in Autistic Disorder.- Alzheimer's Disease and Reelin.- Reelin and Stroke.- Reelin and Pancreatic Cancer.