Regenerative Medicine - from Protocol to Patient

Regenerative medicine is the main field of groundbreaking medical development and therapy using knowledge from developmental and stem cell biology as well as advanced molecular and cellular techniques. This collection of volumes, Regenerative Medicine: From Protocol to Patient, aims to explain the scientific knowledge and emerging technology as well as the clinical application in different organ systems and diseases. International leading experts from all over the world describe the latest scientific and clinical knowledge of the field of regenerative medicine. The process of translating science of laboratory protocols into therapies is explained in sections on regulatory, ethical and industrial issues. The collection is organized into five volumes: (1) Biology of Tissue Regeneration, (2) Stem Cell Science and Technology, (3) Tissue Engineering, Biomaterials and Nanotechnology, (4) Regenerative Therapies I, and (5) Regenerative Therapies II. The textbook gives the student, the researcher, the health care professional, the physician and the patient a complete survey on the current scientific basis, therapeutical protocols, clinical translation and practiced therapies in regenerative medicine.
Volume 3: Tissue engineering, Biomaterials and Nanotechnology focuses the development of technologies, which enable an efficient transfer of therapeutic genes and drugs exclusively to target cells and potential bioactive materials for clinical use. Principles of tissue engineering, vector technology, multifunctionalized nanoparticles, biodegradable materials, controlled release, and biointerface technology are described with regard to the development of new clinical cell technology. Imaging and targeting technologies as well as biological aspects of tissue and organ engineering are depicted.

Basic molecular mechanisms of human stem cell differentiation Molecular mechanisms and technologies for (re-)programming Analytical methods to classify stem cell fate and function Specific features of different human stem cell types Physiology and pathology of stem cells Includes supplementary material: sn.pub/extras

Autorentext
Gustav Steinhoff initiated and leads the Reference and Translation Center for Cardiac Stem Cell Therapy (RTC) of the University Medical Center Rostock. He is known as an expert in the medical field of stem cell therapies and the first clinician to treat patients with intramyocardial transplantation of purified stem cells and is one of the pioneers of these new therapies. Besides his medical study at the Erasmus University Rotterdam, Gustav Steinhoff performed research at the Baylor College in Houston, Texas. He has worked as a surgeon at the University of Kiel and the Medical School Hannover, where he was appointed as an Associate Professor of Cardiothoracic Surgery in 1998. In 2000 he moved to the University of Rostock as a Director and Chairman of the Department of Cardiac Surgery where he continued his research on cardiac stem cell therapies and tissue engineering.

Inhalt
1 Novel technologies in design and fabrication of the 'living' bioprosthetic heart valves; natural scaffolds and synthetic polymers, Rosaria Santoro and Maurizio Pesce.- 2 Recent Progress in Strategies for Adenovirus Mediated Therapeutic Cell Targeting, Ottmar Herchenröder, Julia Reetz, and Brigitte M. Pützer .- 3 Regenerative chimerism bioengineered through stem cell reprogramming, Timothy J. Nelson , Almudena Martinez-Fernandez , Satsuki Yamada , and Andre Terzic.- 4 Biodegradable materials, Michael Schroeter, Britt Wildemann, and Andreas Lendlein.- 5 Biomaterials-Enabled Regenerative Medicine in Corneal Applications, Naresh Polisetti, Geeta K. Vemuganti, May Griffith.- 6 Functionalized Nanomaterials, Jie Zhou, Wenzhong Li, and Changyou Gao.- 7 Biointerface technology, Joachim Rychly.- 8 Controlled Release Technologies for RNAi Strategies in Regenerative Medicine, Jan Hoyer, Michael C. Hacker, Michaela SchulzSiegmund.- 9 Imaging technology, Cajetan Lang and Sebastian Lehner.- Index<