Regulatory T Cells in Health and Disease

Regulatory T Cells in Health and Disease focuses on the mechanism by which T cells become regulatory T cells, the processes which control the number of regulatory T cells in the blood and tissue, and the ways in which regulatory T cell prevent autoimmune disease and interact with infections and cancer.

Autorentext
Adrian Liston is Professor in Autoimmune Genetics at the University of Leuven and the VIB, Belgium. His PhD research was on T cell tolerance and diabetes with Professor Chris Goodnow at the Australian National University, followed by post-doctoral research on regulatory T cell biology with Professor Sasha Rudensky at the University of Washington. The Liston laboratory is supported by an ERC Start Grant, a JDRF Career Development Award, a VIB Investigators Award and grants from the FWO and KUL. Adrian Liston has published more than 70 papers, with over 3000 citations, including key publications on the function of Aire in thymic tolerance, defective tolerance in the NOD mouse, the contribution of immunodeficiency to autoimmunity, microRNA function in regulatory T cells, the discovery of the follicular regulatory T cell, the role of microRNA in the thymic epithelium and the homeostatic control over regulatory T cells.

Inhalt

1. Transcriptional and Epigenetic Regulation of Regulatory T Cell Development
   *Yohko Kitagawa, James Badger Wing and Shimon Sakaguchi*
2. Microenvironment Matters: Unique Conditions within Gut Draining Lymph Nodes Favor Efficient de Novo Induction of Regulatory T Cells
   *Maria Pasztoi, Joern Pezoldt and Jochen Huehn*
3. The Roles of the Nf-?b Pathway in Regulatory T Cell Development and Function
   *Thomas S. Fulford, Darcy Ellis and Steve Gerondakis*
4. The Molecular Control of Regulatory T Cell Induction
   *Annemarie van Nieuwenhuijze and Adrian Liston*
5. The Special Relationship in the Development and Function of T Helper 17 and Regulatory T Cells
   *Matthias Lochner, Zuobai Wang and Tim Sparwasser*
6. Mechanisms of Surveillance of Dendritic Cells by Regulatory T Lymphocytes
   *Maxime Dhainaut and Muriel Moser*
7. Development and Function of Effector Regulatory T cells
   *Peggy P. Teh, Ajithkumar Vasanthakumar and Axel Kallies*
8. Treg Cell Differentiation: from Thymus to Peripheral Tissue
   *David M. Richards, Michael Delacher, Yael Goldfarb, Danny Kägebein, Ann-Cathrin Hofer, Jakub Abramson and Markus Feuerer*
9. Regulatory T Cells in Arthritis
   *Noriko Komatsu and Hiroshi Takayanagi*
10. The Immune Fulcrum: Regulatory T Cells Tip the Balance Between Pro- and Anti-Inflammatory Outcomes Upon Infection
    *Laura E. Richert-Spuhler and Jennifer M. Lund*
11. Regulatory T Cells in Autoimmune Diabetes: Mechanisms of Action and Translational Potential
    *Vitalijs Ovcinnikovs and Lucy S.K. Walker
    *