Resistance to Targeted Therapies Against Adult Brain Cancers

This volume will bring together a review of research being carried out by international experts in this field, detailing treatment and research approaches in several forms of malignant brain tumors. These include glioblastoma (GBM), a highly aggressive and fatal form of astrocytoma which accounts for 80% of newly diagnosed brain tumor patients per year, and meningioma, of which 10% are malignant and extremely resistant to targeted therapies. The volume will also include a discussion of methods to overcome blood-brain barrier exclusion for more efficient targeted drug delivery in all forms of brain cancer treatment. The volume will include information on the repurposing of drugs in an attempt to circumvent drug resistance, use of small molecule inhibitors in GBM treatment, mechanisms of secondary brain metastasis, drug resistance, and state-of-the-art imaging of targeted therapies.

Autorentext
Amanda Tivnan, PhD, is Senior Postdoctoral Research Fellow, Department of Physiology and Medical Physics, The Royal College of Surgeons, Dublin, Ireland.

Inhalt

Targeted therapies in gliomas: An overview.- Targeting chemotherapy resistance in glioblastoma through modulation of ABC transporters.- Resistance of Glioblastomas to Radiation Therapy.- The blood-brain barrier in glioblastoma multiforme: Pathology and therapeutic implications.- Resistance of brain tumours to small-molecule targeted therapies: lessons from various cancer types.- Drug repurposing to circumvent chemotherapy resistance in brain tumours.- Small molecule inhibitors in glioblastoma: Key pathways and resistance mechanisms.- Imaging Targeted Therapy Response and Resistance in Glioblastoma.- Drug Resistance in Malignant Meningiomas.- Recurrence of Low-Grade Glioma - Have the Targeted Therapies Improved for Better Outcomes?.- Host-Tumor Interactions in Brain Cancer Metastasis Leading to Drug Resistance.