Retrovirus-Cell Interactions

Retrovirus-Cell Interactions provides an up-to-date review of the interactions between retroviruses and the cells they infect, offering a comprehensive understanding of how retroviruses hijack cellular factors to facilitate virus replication. Drugs targeting viral enzymes have been developed to treat HIV; the next challenge is to inhibit virus-cell interactions as next generation treatment strategies. Organized according to the retrovirus' replication cycle, this book does not focus exclusively on HIV, but rather includes important findings in other retroviral systems, including animal retroviruses, retrotransposons, and endogenous retroelements to allow broad comparisons on important commonalities and differences.

Autorentext
Physician, Professor of Medicine, Co-Director of the MD/PhD Program, Co-Leader of the Penn State CTSI Pilot and Collaborative Translational and Clinical Studies Penn State College of Medicine

Klappentext
Retrovirus-Cell Interactions provides an up-to-date review of the interactions between retroviruses and the cells they infect, offering a comprehensive understanding of how retroviruses hijack cellular factors to facilitate virus replication. Drugs targeting viral enzymes have been developed to treat HIV; the next challenge is to inhibit virus-cell interactions as next generation treatment strategies. Organized according to the retrovirus' replication cycle, this book does not focus exclusively on HIV, but rather includes important findings in other retroviral systems, including animal retroviruses, retrotransposons, and endogenous retroelements to allow broad comparisons on important commonalities and differences.

Inhalt

1. Retrovirus Receptor Interactions and Entry
   Lorraine M. Albritton
   
   2. Cellular Factors That Regulate Retrovirus Uncoating and Reverse Transcription
      Stephen P. Goff
   3. Nucleoporins in Retroviral Replication: What's Nup Got to Do with It?
      Anne Monette and Andrew J. Mouland
   4. Virus-Host Interactions in Retrovirus Integration
      Alan N. Engelman and Goedele N. Maertens
   5. Transcriptional Control and Latency of Retroviruses
      Bryan C. Nikolai and Andrew P. Rice
   6. Teetering on the Edge: The Critical Role of RNA Processing Control During HIV-1 Replication
      Ahalya Balachandran, Liang Ming and Alan Cochrane
2. Nuclear RNA Helicases Support Early and Late Events in Retroviral Replication
   Gatikrushna Singh, Xiao Heng and Kathleen Boris-Lawrie
   
   8. Role of Host Factors in the Subcellular Trafficking of Gag Proteins and Genomic RNA Leading to Virion Assembly
      Eunice C. Chen and Leslie Parent
   9. Tumor Suppressor Gene 101: A Virus' Multifunctional Conduit to the ESCRT Trafficking Machinery
      Carol A. Carter
   10. The Role of Lipids in Retroviral Replication
       Abdul A. Waheed and Eric O. Freed
   11. Cellular Immune Responses to Retroviruses
       Susan R. Ross
   12. Noncoding RNAs in Retrovirus Replication
       Alice A. Duchon and Karin Musier-Forsyth
   13. Cellular Control of Endogenous Retroviruses and Retroelements
       Suzanne Sandmeyer
   14. Strategies to Discover Novel Cellular Factors Involved in Retrovirus Replication
       Rebecca J. Kaddis Maldonado, Eunice C. Chen and Leslie Parent