Review article on Solid Phase Synthesis

The first concept of solid phase synthesis was performed by Merrifield (1) in a dipeptide synthesis from two amino acids. Not surprisingly, Solid phase synthesis did not remain limited to peptides, but also it was extended to heterocycles, so many synthesis methods in solution phase had been transferred to solid phase processes.So, solid phase organic synthesis had become very attractive route of synthesis due to its simplicity of separation of synthetic intermediates from soluble components of a reaction mixture by simple filtration and washing of the resin bound reaction product.

Autorentext

Solid phase organic synthesis is a technique that is characterized by its simplicity, where reactions on solid phase are performed by shaking a support (resin) with a mixture of solvents and reagents for a given time, filtering the mixture, and washing the support with suitable solvents. Cleavage of the product often yields products of high yield.