RGS Protein Physiology and Pathophysiology

RGS Protein Physiology and Pathophysiology describes the current, state-of-the-art research occurring in the laboratories of leaders in the RGS protein field that utilize genetic mouse models to interrogate the function of RGS proteins in vivo.

Each chapter describes the elucidated role of a specific RGS protein or family of RGS proteins in normal physiology and/or disease with particular emphasis on how these discoveries inform healthcare and drug discovery.

The work is a timely reference as drugs targeting G protein coupled receptors represent 40% of currently marketed therapeutics.

Autorentext
Dr. Fisher is a 1983 graduate of Iowa State University (Ph.D.), who performed post-doctoral research at the University of Texas Health Science Center, San Antonio, before joining the faculty in Pharmacology at the University of Iowa in 1987. He was promoted to associate professor in 1993 and to professor in 2004. He has a secondary appointment in the Department of Internal Medicine and is a member of the Molecular and Cellular Biology interdisciplinary graduate program, the Holden Cancer Center, the Medical Scientist Training Program, and the Gene Therapy Center. His research focuses on the biology and signaling of RGS proteins and G proteins. He has served on numerous NIH study sections and his funding includes an R01 to study novel actions of RGS6 in tumor suppression and DNA damage signaling.

Inhalt

1. Introduction: G Protein-coupled Receptors and RGS Proteins
   *Adele Stewart and Rory A. Fisher*
2. RGS-insensitive G Proteins as in vivo Probes of RGS Function
   *Richard R. Neubig*
3. RGS Protein Regulation of Phototransduction
   *Ching-Kang Jason Chen*
4. Role of Regulators of G Protein Signaling (RGS) Proteins in Bone Physiology and Pathophysiology
   *Joel Jules, Shuying Yang, Wei Chen and Yi-Ping Li*
5. Regulator of G Protein Signaling 2: A Versatile Regulator of Vascular Function
   *Patrick Osei-Owusu and Kendall J. Blumer*
6. Keeping the Balance Right: Regulator of G Protein Signaling 5 in Vascular Physiology and Pathology
   *Ruth Ganss*
7. Two for the Price of One: G Protein-Dependent and -Independent Functions of RGS6 in vivo
   *Adele Stewart, Biswanath Maity and Rory A. Fisher*
8. Physiology of RGS10 in Neurons and Immune Cells
   *Jae-Kyung Lee and Malú G. Tansey*
9. Regulator of G Protein Signaling 14 (RGS14): A Molecular Brake for Synaptic Plasticity Linked to Learning and Memory
   *Paul R. Evans, Serena M. Dudek and John R. Hepler
   *