ROLE OF EMMPRIN, CyPA, MMP-1 AND MMP-2 IN PERIODONTITIS

Matrix Metalloproteinases (MMPs) are the most important enzymes for Extracellular matrix maintenance. MMPs are also involved in several biological and pathological diseases. They are a great challenge for science due to its high complexity in regulation and activity. MMPs are regulated by EMMPRIN through paracrine manner or through cell-to-cell interaction. Cyclophilin A (CyPA) expression is correlated with MMP-1, MMP-2 and MMP-9 expression in inflamed gingiva. CyPA plays an important role in biological conditions like T-cell activation, protein folding and trafficking. Understanding its role in the development of diseases and its mode of action requires more studies.

Autorentext

Dr. Anita Mehta working as Professor in the Department of Periodontics at DIRDS, Faridkot. This book is PhD thesis. Dr. Vikram Bali is working as Professor and Head in the Department of Periodontics at DBDC. Dr. Pradeep Shukla is working as Professor and Head in the Department of Periodontics at D.J College of Dental Sciences and Research.