Role of Mast Cell Stabilizers in Gingival Enlargement

Aim: To histo-morphologically compare the mast cell density, epithelium thickness, mean vessel density in the gingiva before and after giving mast cell stabilizers. Settings and Design: The present cross-sectional study was conducted on 45 patients diagnosed with chronic periodontitis. Gingival biopsies were obtained from 45 patients categorized into 2 groups: group 1 before giving mast cell stabilizers and group 2 after giving mast cell stabilizers. The groups were sub-categorized as smokers and non-smokers. The epithelial thickness, mean vessel density and number of mast cells were assessed using histo-morphometric analysis. Results of this study revealed that the mean mast cell density and mean vessel density decreased after giving mast cell stabilizers in group 2 compared to group 1. There was no significant difference in the epithelium thickness between both the groups. Conclusion: Mast cells play a crucial role in the sustenance and progression of periodontal disease as mean mast cell density was high before giving mast cell stabilizers.

Autorentext

Ich bin Zahnmedizinerin mit Spezialisierung auf orale Pathologie und Mikrobiologie.