Role of Statins in the Management of Periodontal Disease

Statins, 3-hydroxy 3-methylglutaryl coenzyme A (HMG-CoA)reductase inhibitors, prescribed to prevent cardiovascular andcerebrovascular diseases.Each year they are among the most prescribed and top-selling drugs in the United States, especially in middle-aged adults. Statins have been reported to also possess anti-inflammatory properties, antibacterial activities, anti-oxidative features and pleiotropic features, such as inhibiting release of pro-inflammatory mediators and matrixmetallo-proteinases (MMPs).Due to such characteristics, statins have been used for treating patients with periodontal diseases aiming to reduce lipopolysaccharide (LPS)-induced MMP-1, MMP-8, and MMP-9 expressions in monocytes as well as expression of MMP-9 in osteoblastic cells.Statins inhibit the release of pro-inflammatory mediators, specifically cytokines(i.e., tumor necrosis factor-a, chemokines, interleukin [IL] family) and matrix metallo-proteinases (MMPs).

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I am a post graduate in and wants to achieve excellence in research and academics in the field of Periodontics and Implantology, where I can empathetically use my experience to provide the best possible care to patients.