Role of TRPV4 Channels in Different Organ Systems: Volume 89

Role of TRPV4 Channels in Different Organ Systems, Volume 89, the latest release in the Current Topics in Membranes series, provides an in-depth description of the role of TRPV4 ion channels in different organ systems under healthy and disease conditions. Research over the last two decades shows crucial physiological and pathological roles for TRPV4 channels. In this volume, we present chapters focusing on TRPV4 channels in the vasculature, lungs, heart, kidney, bladder, skin, musculoskeletal system, eye, and immune cells. Understanding the behavior of TRPV4 channels in various organ systems will provide a big picture on their physiological roles and therapeutic targeting.

Autorentext
Swapnil Sonkusare is an Associate Professor in Molecular Physiology and Biological Physics and a Resident Faculty in the Robert M. Berne Cardiovascular Research Center at the University of Virginia, Charlottesville. His research focuses on the regulation of blood flow and blood pressure by calcium signaling mechanisms in the vascular wall. He has investigated vascular calcium channels in health and disease throughout his scientific career. His main goals are to define the abnormalities in vascular calcium signaling mechanisms in cardiovascular disorders and to identify novel therapeutic targets. His laboratory routinely uses high-end calcium imaging, superresolution imaging, patch-clamp electrophysiology, vascular assays, mouse models of vascular disorders, and transgenic mice. Current NIH- and AHA-funded studies in my laboratory use this unique combination of techniques to address 1) new calcium signaling mechanisms that control vascular contractility and blood pressure in systemic and pulmonary vasculature; 2) contribution of impaired vascular calcium signaling and vascular inflammation to obesity-induced hypertension.

Inhalt

Preface
Swapnil K. Sonkusare
1. TRPV4-dependent signaling mechanisms in systemic and pulmonary vasculature
Zdravka Daneva and Maniselvan Kuppusamy
2. Endothelial TRPV4 channels in lung edema and injury
Swapnil K. Sonkusare and Victor E. Laubach
3. Cardiac TRPV4 channels
Vivian C. Onyali and Timothy L. Domeier
4. Evolving concepts of TRPV4 in controlling flow-sensitivity of the renal nephron
Kyrylo Pyrshev, Anna Stavniichuk, Viktor N. Tomilin, Oleg Zaika and Oleh Pochynyuk
5. Transient receptor potential vanilloid type 4 (TRPV4) in urinary bladder structure and function
Megan Elizabeth Perkins and Margaret A. Vizzard
6. The role of TRPV4 channels in cutaneous epithelia
Carlene Moore
7. Function and regulation of thermosensitive ion channel TRPV4 in the immune system
Tusar Kanta Acharya, Ram Prasad Sahu, Satish Kumar, Shamit Kumar, Tejas Pravin Rokade, Ranabir Chakraborty, Nishant Kumar Dubey, Deep Shikha, Saurabh Chawla and Chandan Goswami
8. TRPV4: Cell type-specific activation, regulation and function across the vertebrate eye
Luka Lapajne, Christopher N. Rudzitis, Brenan Cullimore, Daniel Ryskamp, Monika Lakk, Sarah Redmon, Oleg Yarishkin and David Krizaj
9. Role of TRPV4 in skeletal function and its mutant-mediated skeletal disorders
Rashmita Das and Chandan Goswami