Safety of Biologics Therapy

This long overdue title provides a comprehensive, up-to-date, state-of-the art review of approved biologic therapies, with coverage of mechanisms of action, Indications for therapy, immunogenicity and a detailed examination of adverse effects and safety of the many and diverse therapeutic agents presented in a total of 13 chapters. It is predicted that by 2016, biologics will make up half of the world's 20 top-selling drugs and by 2018, biologic medicine sales will account for almost half of the world's 100 biggest selling drugs. Recombinant proteins dominate the growing list of the more than 200 approved biotherapeutic agents with targeted antibodies, fusion proteins and receptors; cytokines; hormones; enzymes; proteins involved in blood-clotting, homeostasis and thrombosis; vaccines; botulinum neurotoxins; and, more recently, biosimilar preparations, comprising the majority of approved biologics. Written with clinicians, other health care professionals, and researchers in mind,Safety of Biologics Therapy examines, in a single volume, the full range of issues surrounding the safety of approved biologic therapies. A good understanding of the risks and safety issues of modern biologics therapy is increasingly being demanded of all those connected with their development, handling, prescribing, administration and subsequent patient management. In addition to being of great value to clinicians in all branches of medicine, and to nurses, pharmacists and researchers, this book will prove invaluable for students taking undergraduate and graduate courses in the above disciplines and in the biomedical sciences.

The only book available that covers in a single volume the full range of issues surrounding safety of approved biologic therapies In addition to presenting a detailed examination of adverse effects and safety The book covers mechanisms of action, Indications for therapy, and immunogenicity of the many and diverse biologic therapeutic agents Written to be definitive and comprehensive Relevant to clinicians in all medical disciplines, nurses, pharmacists, biomedical scientists, as well as students in these health care disciplines

Autorentext
Brian A. Baldo (Retired)AUA(Pharmacy); BSc(Hons); PhDFormerly: Royal North Shore Hospital of SydneyHead, Molecular Immunology UnitKolling Institute of Medical Research and University of SydneySydney, NSW AUSTRALIA

Inhalt
1: Approved Biologics Used For Therapy and their Adverse Effects.- 2: Monoclonal Antibodies: Introduction.- 3: Monoclonal Antibodies Approved for Cancer Therapy.- 4: Other Approved Therapeutic Monoclonal Antibodies.- 5: Cytokines.- 6: Fusion Proteins.- 7: Peptide Hormones.- 8: Glycoprotein Hormones.- 9: Enzymes Approved for Therapy.- 10: Blood Coagulation.- 11: Vaccines.- 12: Botulinum Neurotoxins.- 13: Biosimilars.