Sarcopenia - Age-Related Muscle Wasting and Weakness

Some of the most serious consequences of aging are its effects on skeletal muscle. This book provides the latest state-of-the-art information on sarcopenia. It includes contributions from some of the world's leading experts in skeletal muscle aging.

State-of-the-art information on aging and skeletal muscle Contributions from some of the world's leading experts in skeletal muscle aging Identifies key neuromuscular mechanisms responsible for sarcopenia Identifies signalling pathways and targets for therapeutic intervention Information has relevance and broad application for researchers and practitioners involved with the study and treatment of aging and its effects on skeletal muscle Includes supplementary material: sn.pub/extras

Inhalt
1.Overview.- 2. Molecular mechanisms of muscle wasting in cancer and ageing: cachexia versus sarcopenia.- 3. Age-related remodeling of neuromuscular junctions.- 4.Motor unit remodeling during aging.- 5. Age-related decline in actomyosin structure and function.- 6. Excitation-contraction coupling in aged skeletal muscle.- 7. Mitochondrial function in aging skeletal muscle.- 8. Fibrosis and skeletal muscle aging.- 9. Nuclear apoptosis and sarcopenia.- 10. Age-related changes in the molecular regulation of skeletal muscle mass.- 11. Genetic variation and skeletal muscle traits: implications for sarcopenia.- 12. Proteomic profiling of aged skeletal muscle.- 13. Aging, exercise and muscle protein metabolism.- 14. Reactive oxygen species generation and skeletal muscle wasting implications for sarcopenia.- 15. Exercise as a countermeasure for sarcopenia.- 16. Role of contraction-induced injury in age-related muscle wasting and weakness.- 17. Role of IGF-I signaling in age-related changes in skeletal muscle.- 18. Role of myostatin and TGF-beta signaling in skeletal muscle growth and development: implications for sarcopenia.- 19. -Adrenergic signaling in sarcopenia and other muscle wasting disorders.