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SB-271,046
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27562923J6A
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Geliefert zwischen Fr., 14.11.2025 und Mo., 17.11.2025
Details
Please note that the content of this book primarily consists of articles available from Wikipedia or other free sources online. SB-271,046 is a drug which is used in scientific research. It was one of the first selective 5-HT6 receptor antagonists to be discovered, and was found through high-throughput screening of the SmithKline Beecham Compound Bank using cloned 5-HT6 receptors as a target, with an initial lead compound being developed into SB-271,046 through a structure-activity relationship (SAR) study. SB-271,046 was found to be potent and selective in vitro and had good oral bioavailability in vivo, but had poor penetration across the blood-brain barrier, so further SAR work was then conducted, which led to improved 5-HT6 antagonists such as SB-357,134 and SB-399,885.
Weitere Informationen
- Allgemeine Informationen
- GTIN 09786130968793
- Editor Lambert M. Surhone, Miriam T. Timpledon, Susan F. Marseken
- Genre Chemie
- Größe H220mm x B220mm
- EAN 9786130968793
- Format Fachbuch
- Titel SB-271,046
- Herausgeber Betascript Publishing
- Anzahl Seiten 124
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