Selective Relaxant Binding Agent
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Details
Selective Relaxant Binding Agents (SRBAs) are a new class of drugs that selectively encapsulates and binds neuromuscular blocking agents (NMBAs). The first drug introduction of an SRBA is sugammadex. Sugammadex is a modified gamma cyclodextrin that specifically encapsulates and binds the aminosteroid NMBAs: rocuroniumvecuroniumancuronium. SRBAs exert a chelating action that effectively terminates an NMBA ability to bind to nicotinic receptors.The discovery of SRBA as a new class of drug is the result of work done by Organon laboratories at the Newhouse research site in Scotland. Cyclodextrins were explored as a means to solubilize rocuronium bromide (a steroidal NMBA) in a neutral aqueous solution. Upon creating numerous modified cyclodextrins, one particular molecule was found to possess extremely high affinity for the rocuronium molecule. Originally known as Org25969, it is now generically named sugammadex sodium.
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GarantieWeitere Informationen
- Allgemeine Informationen
- GTIN 09786138552024
- Editor Dagda Tanner Mattheus
- Sprache Englisch
- Auflage Aufl.
- Genre Chemie
- Größe H220mm x B220mm
- Jahr 2011
- EAN 9786138552024
- Format Kartonierter Einband (Kt)
- ISBN 978-613-8-55202-4
- Titel Selective Relaxant Binding Agent
- Untertitel Sugammadex, Rocuronium Bromide
- Herausgeber VENT
- Anzahl Seiten 52
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