Self-Assembled Molecules - New Kind of Protein Ligands

An up-to-date account of supramolecular ligands
Essential reading for academic and industrial scientists interested in drug targeting

A comprehensive overview of the enhancement of immune complexation

An up-to-date account of supramolecular ligands Essential reading for academic and industrial scientists interested in drug targeting A comprehensive overview of the enhancement of immune complexation

Autorentext

Dr Irena Roterman-Konieczna professor of bioinformatics **** heads the bioinformatics group at the Jagiellonian University Medical College and the Faculty of Physics, Astronomy and Applied Computer Science, Poland. Her background is the theoretical chemistry and her research focuses on bioinformatics with a special focus on protein structure prediction. Involved also in education of medical students and students of computer science developing different forms of simulations in medicine.

Klappentext

This book is an open access under a CC BY license.

The subject of this book relates to protein ligands with particular structural and complexation properties. They are composed of self-assembled molecules, capable of penetrating as a unit into proteins outside the binding site. The ribbon-like supramolecular system only permits the penetration of self-assembled molecules into the protein-body and formation of stable complexes. Supramolecular Congo red and similar compounds fit these requirements. Destabilized protein fragments enable the penetration of such ligands, with susceptibility to supramolecular ligand binding often associated with protein function. As a result, complexation modifies their functional effects. The activity of enzymes is inhibited by arresting them in the complexed state, but naturally irreversible complexation as in the case of immune complexation, is enhanced instead. This property offers many attractive possibilities of using supramolecular ligands as described in this book.

Zusammenfassung
An up-to-date account of supramolecular ligands
Essential reading for academic and industrial scientists interested in drug targeting

A comprehensive overview of the enhancement of immune complexation

Inhalt

Supramolecular Protein Ligands Unexplored Teritory Of Potential Pharmacological Activity.- Supramolecular Congo Red As Specific Ligand Of Antibodies Engaged In Immune Complex.- Protein Conditioning For Binding Congo Red And Other Supramolecular Ligands.- Metal Ions Introduced To Proteins By Supramolecular Ligands.- Possible Mechanism Of Amyloidogenesis Of V Domains.- Supramolecular Structures As Carrier Systems Enabling The Use Of Metal Ions In Antibacterial Therapy.- Congo Red Interactions With Single-Walled Carbon Nanotubes.