Separation Methods in Drug Synthesis and Purification: Volume 8

Separation Methods in Drug Synthesis and Purification, Second Edition, Volume Eight, provides an updated on the analytical techniques used in drug synthesis and purification. Unlike other books on either separation science or drug synthesis, this volume combines the two to explain the basic principles and comparisons of each separation technique. New sections to this volume include enantiomer separation using capillary electrophoresis (CE) and capillary electro- chromatography, the computer simulation of chromatographic separation for accelerating method development, the application of chromatography and capillary electrophoresis used as surrogates for biological processes, and new developments in the established techniques of chromatography and preparative methods.

Autorentext
Dr. Klára Valkó is an enthusiastic principal scientist and consultant supporting early drug discovery and lead optimization with over 22 years of experience. She has been an Honorary Professor at UCL School of Pharmacy since 2004, leading the Physchem/ADME module (London, UK) for Drug Discovery MSc. Her many contributions to the field include the development of biomimetic HPLC methods for high throughput measurements of serum albumin, glycoprotein and phospholipid binding, the invention of the Chromatographic Hydrophobicity Index for fast determination of compounds' lipophilicity using generic gradient reversed phase chromatography, and more.

Inhalt

Preface Klara Valko

1. Comparison of various modes and phase systems for analytical HPLC

   Pavel Jandera

2. Fast-generic HPLC methods

   Ian M. Mutton

3. Advances in capillary electrochromatography

   José Luís Dores-Sousa, Jelle De Vos, Debby Mangelings and Sebastiaan Eeltink

4. Coupled chromatographyemass spectrometry techniques for the analysis of combinatorial libraries

   Steve Lane

5. Experimental design-based optimization strategies for chromatographic and capillary electrophoretic separations

   J. Viaene and Y. Vander Heyden

6. Computer-aided HPLC method development for quality control of complex drug mixtures--An application example for DryLab

   Halina Katsialevich, Hans-Jürgen Rieger, Imre Molnár and Arnold Zöldhegyi

7. The flexible application of automated preparative purification platforms within drug discovery

   Jennifer Kingston, Neil Sumner, Katie Proctor and Elisabetta Chiarparin

8. Strategies for the development of process chromatography as a unit operation for the pharmaceutical industry

   Drew Katti

9. Recent developments in liquid and supercritical fluid chromatographic enantioseparations

   Debby Mangelings, Sebastiaan Eeltink and Yvan Vander Heyden

10. Basis and pharmaceutical applications of thin-layer chromatography

    Huba Kalász, Mária Báthori and Klára Valko

11. Recent advances in quantitative structureeretention relationships

    Roman Kaliszan

12. Capillary electrophoresis for drug analysis and physicochemical characterization

    Susana Amézqueta, Xavier Subirats, Elisabet Fuguet, Clara Ràfols and Martí Rosés

13. Application of HPLC measurements for the determination of physicochemical and biomimetic properties to model in vivo drug distribution in support of early drug discovery

    Klára L. Valkó