Serpin Structure and Evolution: Volume 501

Klappentext Serpins are a group of proteins with similar structures that were first identified as a set of proteins able to inhibit proteases. This volume in the Methods in Enzymology series comprehensively covers this topic. With an international board of authors, this volume covers subjects such as Crystallography of serpins and serpin complexes, Serpins as hormone transporters, and Production of serpins using cell free systems. Zusammenfassung Serpins are a group of proteins with similar structures that were first identified as a set of proteins able to inhibit proteases. Part of the "Methods in Enzymology" series! this title covers subjects such Crystallography of serpins and serpin complexes! Serpins as hormone transporters! and Production of serpins using cell free systems. Inhaltsverzeichnis 1. Development of inhibitors of PAI-1 Daniel Lawrence 2. Kinetics of Serpin interactions with cofactors and proteases Steven Olson 3. Fluorescence Correlation Spectroscopy (FCS) or Single molecule FRET Anne Gershenson 4. Serpin-enzyme receptors (LRP) Dudley Strickland 5. Predicting serpin / protease interactions Jiangning Song 6. Serpins and autophagy David Perlmutter 7. Plant Serpins Tom Roberts 8. High throughput Drug discovery Bibek Gooptu 9. Use of mouse models to study maspin function Ming Zhang 10. The study of antitrypsin deficiency using animal models Jeffrey Teckman 11. Use of Mouse Models to study PAI-1 Paul Declerck 12. Production of serpins using cell free systems Clifford Luke 13. Studying serpin polymerisation in vitro James Huntington 14. Serpins and neural function Denis Monard 15. Probing serpin conformational change using mass spectrometry and related methods Patrick Wintrode 16. Studying Serpin conformational change Randy Read 17. Production of serpins in bacteria Mary Pearce 18. Inhibition of cysteine proteases by serpins Jan Potempa 19. Post transcriptional regulation of serpins Rob Medcalf 20. Serpins and the complement system Rob Pike & Lakshmi Wijeyewickrema 21. Serpins in Caenorhabditis elegans Stephen Pak & Gary Silverman 22. PEDF and angiogenesis Patricia Becerra 23. The Serpinb1 knockout mouse Charaf Benarafa 24. Biophysical approaches to studying serpin folding Steve Bottomley 25. TALS for studying the proteases inhibited by Serpins Chris Overall ...

Inhalt

1. Development of inhibitors of PAI-1

   Daniel Lawrence

   2. Kinetics of Serpin interactions with cofactors and proteases

   Steven Olson

   3. Fluorescence Correlation Spectroscopy (FCS) or Single molecule FRET

   Anne Gershenson

   4. Serpin-enzyme receptors (LRP)

   Dudley Strickland

   5. Predicting serpin / protease interactions

   Jiangning Song

   6. Serpins and autophagy

   David Perlmutter

   7. Plant Serpins

   Tom Roberts

   8. High throughput Drug discovery

   Bibek Gooptu

   9. Use of mouse models to study maspin function

   Ming Zhang

   10. The study of antitrypsin deficiency using animal models

   Jeffrey Teckman

   11. Use of Mouse Models to study PAI-1

   Paul Declerck

   12. Production of serpins using cell free systems

   Clifford Luke

   13. Studying serpin polymerisation in vitro

   James Huntington

   14. Serpins and neural function

   Denis Monard

   15. Probing serpin conformational change using mass spectrometry and related methods

   Patrick Wintrode

   16. Studying Serpin conformational change

   Randy Read

   17. Production of serpins in bacteria

   Mary Pearce

   18. Inhibition of cysteine proteases by serpins

   Jan Potempa

   19. Post transcriptional regulation of serpins

   Rob Medcalf

   20. Serpins and the complement system

   Rob Pike & Lakshmi Wijeyewickrema

   21. Serpins in Caenorhabditis elegans

   Stephen Pak & Gary Silverman

   22. PEDF and angiogenesis

   Patricia Becerra

   23. The Serpinb1 knockout mouse

   Charaf Benarafa

   24. Biophysical approaches to studying serpin folding

   Steve Bottomley

   25. TALS for studying the proteases inhibited by Serpins

   Chris Overall