Sesquiterpene Lactones

Presents an essential update on the state of knowledge concerning the chemistry and bioactivity of sesquiterpene lactones

Discusses the potential of sesquiterpene lactones as lead molecules for the development of new drugs

Provides an overview of the most commonly used techniques for the isolation, identification and evaluation of sesquiterpene lactones' antiprotozoal and antiproliferative activity

Autorentext

Prof. Dr. Valeria P. Sülsen: Valeria P. Sülsen has a Pharmacy B.Sc. (1998) and Ph.D. (2009) from University of Buenos Aires, Argentina. She got a Posdoctoral Research Fellowship at the Institute of Chemistry and Metabolism of Drugs (IQUIMEFA), University of Buenos Aires National Scientific and Technical Research Council (CONICET) from 2009 to 2011. In 2011, she received the Felix de Azara Award for the best work on flora and fauna of Argentina (Faculty of Pharmacy and Biochemistry, University of Buenos Aires, Argentina) and the Award for the Best Thesis (Faculty of Pharmacy and Biochemistry, University of Buenos Aires, Argentina), in 2009. Nowadays she is a Researcher of The National Scientific and Technical Research Council working at Institute of Chemistry and Metabolism of Drugs (IQUIMEFA) University of Buenos Aires and member of the research network Natural Products against Neglected Diseases (NPND). She is Assistant Professor of Pharmacognosy, Faculty of Pharmacy and Biochemistry, University of Buenos Aires, Argentina. Her main expertise areas are pharmacognosy and antiprotozoal natural products.

Prof. Dr. Virginia S. Martino: She has a Pharmacy B.Sc. (1970) and Ph.D. (1983) from University of Buenos Aires, Argentina. Specialist in Policy and Management of Science and Technology (2011). She joined the National Scientific and Technical Research Council in 1982 working at the Institute of Chemistry and Metabolism of Drugs (IQUIMEFA) Faculty of Pharmacy and Biochemistry-University of Buenos Aires. She is member of the National Academy of Pharmacy and Biochemistry (Argentina). Awards received: Felix de Azara (Faculty of Pharmacy and Biochemistry, University of Buenos Aires, Argentina) (1984, 1989, 2011); Dr. Bernardo Houssay (2003)(CEDIQUIFA); Dr. Alfredo Bandoni (1993) (National Academy of Pharmacy and Biochemistry). She was Head Professor of Pharmacognosy at the Faculty of Pharmacy and Biochemistry, University of Buenos Aires between 2005 and 2014.

Inhalt
Part1. Chemical and biochemical aspects of sesquiterpene lactones.- Chapter1. Overview.- Chapter2. Ancient and modern concepts about the asteraceae taxonomy.- Chapter3. Chemotaxonomic study of sesquiterpene lactones of asteraceae: classical and modern methods.- Chapter4. Biosynthesis of sesquiterpene lactones in plants and metabolic engineering for their biotechnological production.- Chapter5. Chemistry of sesquiterpene lactones.- Chapter6. Analytical procedures.- Chapter7. Spectroscopic methods for the identification of sesquiterpene lactones.- Part2. Biological activities of sesquiterpene lactones.- Chapter8. Antitrypanosomal and antileishmanial activities.- Chapter9. Antiplasmodial activity.- Chapter10. Mode of action on trypanosoma and leishmania spp.- Chapter11. Contribution of microscopy for understanding the mechanism of action against trypanosomatids.- Chapter12. Effects on other microorganisms.- Chapter13. Antiproliferative and cytotoxic activities.- Chapter14. Anti-inflammatory activity.- Part3. Sesquiterpene lactones: medicinal chemistry approach.- Chapter15. Structure-activity and activity-activity relationships of sesquiterpene lactones.