Shock, Sepsis, and Organ Failure

At the Sixth Wiggers Bernard Conference, a group of scientists from various fields discussed new findings relating to nitric oxide synthase inhibitor in shock, sepsis, and organ failure. This meeting was dedicated to the presentation and discussion of positive and negative findings related to the use of NOS inhibitors, the issue of specific and non-specific inhibitors and the role of nitric oxide-oxygen radical interactions. Both experimental and clinical data were presented in the trauma and sepsis field. With appropriate dosing and timing the use of NOS inhibitors seems to be beneficial at least in severe sepsis situations, but some inhibitors and overdosing can be potentially dangerous.

Includes supplementary material: sn.pub/extras

Inhalt
Inhibition of the Overproduction of Nitric Oxide in Septic Shock Using NG-Methyl-L-Arginine.- Successful Administration of the NO Synthase Inhibitor 546C88 as a Delayed Continous Infusion in a Baboon Model of Septic Shock.- Clinical Aspects of Nitric Oxide (NO?) Blockade with Pyridoxylated-Hemoglobin Polyoxyethylene Conjugate (PHP).- Norepinepherine Versus L-NMMA in Hyperdynamic Septic Shock.- Roles for Induced Nitric Oxide in Endotoxic and Hemorrhagic Shock.- Role of Nitric Oxide in the Regulation of Cardiovascular Performance: Clinical Implication for Sepsis and Congestive Heart Failure.- Inducible NOS and Other Novel Mediators of Inflammation in Brain Trauma.- Nitric Oxide and Leukocyte Adhesion: Experience with NO Inhibitors, NO Donors and iNOS-Deficient Mice.- Cytokine Control of Nitric Oxide Production: Therapeutic Possibilities.- Peroxynitrite: the Dark Side of Nitric Oxide-Effect of Mercaptoethylguanidine (MEG), a Combined Inhibitor of Inducible Nitric Oxide Synthase and Scavenger of Peroxynitrite in Shock, Inflammation, and Ischemia-Reperfusion Injury.- Actions of Selective and Non-Selective Nitric Oxide Synthase Inhibitors on Multiple-Organ Microvascular Injury Provoked by Lipopolysaccharide.- Inhibition of Nitric Oxide Synthases by the 4-Amino Analogue of Tetrahydrobiopterin.- Effects of Nitric Oxide Inhibitors and Hemoglobin in Sepsis.