Side Reactions in Peptide Synthesis

*Side Reactions in Peptide Synthesis,* based on the author's academic and industrial experience, and backed by a thorough review of the current literature, provides analysis of, and proposes solutions to, the most frequently encountered side reactions during peptide and peptidomimetic synthesis.

This valuable handbook is ideal for research and process chemists working with peptide synthesis in diverse settings across academic, biotech, and pharmaceutical research and development.

While peptide chemistry is increasingly prevalent, common side reactions and their causes are often poorly understood or anticipated, causing unnecessary waste of materials and delay.

Each chapter discusses common side reactions through detailed chemical equations, proposed mechanisms (if any), theoretical background, and finally, a variety of possible solutions to avoid or alleviate the specified side reaction.

Autorentext
Yi Yang began researching peptide synthesis in 2003, and obtained his doctoral degree at Bielefeld University, Germany in 2008. Dr. Yang worked for three years at Lonza AG, Visp, Switzerland as R&D and Process Peptide Chemist, participated in multi cGMP peptidyl API production at Lonza, which is regarded as one of the largest peptide contract manufacturing organization (CMO) in the world, serving pharmaceutical companies. He is currently the Senior Research Scientist of Chemical Development, Global Pharmaceutical R&D, Ferring Pharmaceuticals A/S, Copenhagen, Denmark. Dr. Yang's experience with a wide variety of peptide side reactions, from both practical and theoretical aspects, is ideal for this publication.

Klappentext

This handbook is ideal for research and process chemists working with peptide synthesis in diverse settings across academic, biotech, and pharmaceutical research and development. While peptide chemistry is increasingly prevalent, common side reactions and their causes are often poorly understood or anticipated, causing unnecessary waste of materials and delay. Each chapter discusses common side reactions through detailed chemical equations, proposed mechanisms (if any), theoretical background, and finally, a variety of possible solutions to avoid or alleviate the specified side reaction.

Zusammenfassung
Based on the author's academic and industrial experience and backed by a thorough review of the literature, this book provides analysis of, and proposes solutions to, the most frequently encountered side reactions during peptide and peptidomimetic synthesis.

Inhalt

1. Peptide Fragmentation/Deletion
2. Premature FMOC Deprotection
3. Elimination Side Reactions
4. Peptide Global Deprotection/Scavenger-Induced Side Reactions
5. Peptide Rearrangement Side Reactions
6. Side Reactions Occurring at Amino Acid/Peptide Activation Step
7. Intramolecular Cyclization Side Reactions
8. Side Reactions in Amino Groups in Peptide Synthesis
9. Side Reactions in Hydroxyl, Carboxyl, Ester Groups in Peptide Synthesis
10. Oxidation and Reduction Side Reactions in Peptide Synthesis
11. Racemization in Peptide Synthesis
12. Solvent and Residual Impurities in the Reagents Induced Side Reactions
13. Dipeptide Formation Side Reactions (Redundant Amino Acid Incorporation)
14. Reattachment of Peptides to the Solid Supports
15. Addition Side Reactions in Peptide Synthesis
16. Side Reactions in Phosphor Peptides
17. Side Reactions in CYS
18. Protein Fragmentations