Simple Economical Flexible apparatus for Solid Phase Peptide Synthesis

This book focuses on the preparation of peptides using manual apparatus which can be prepared in the laboratories. Solid phase peptide synthesis basically involves repetitive deblocking and coupling reactions. In order to make these repetitive operations fast and convenient, the deblocking and coupling reactions are carried out in specially designed apparatus, which are called solid phase peptide synthesis apparatus. In this book using the two vessel approach the synthesis of enkephalins modified at fifth position is described. Enkephalins are pentapeptides (Tyr-Gly-Gly-Phe-Met), and are produced endogenously to relieve pain. The suitability and flexibility of two-vessel approach is further demonstrated by synthesizing enkephalin derivatives involving lengthy reactions.

Autorentext

KVRC Rajesh Kumar, M.Pharm, Manipal College of Pharmaceutical sciences India, Experience - 5 years in formulations & Analytical Research, worked in NATCO R&D. Current position- Assistant Manager, Regulatory Affairs Department, Dr. Reddy''s Laboratories Ltd, India Intrests-Research and Development in Novel drug delivery systems