Simultaneous Estimation of Aliskiren and Valsartan by Using HPLC

This work is aimed to develop a simple, precise and accurate HPLC method for the assay of Aliskiren and Valsartan. Aliskiren hemifumarate is a direct renin inhibitor and is indicated for essential hypertension. Valsartan is a nonpeptide specific angiotensin II receptor blocker and is indicated for the treatment of hypertension. The combination of Aliskiren and Valsartan is indicated for the treatment of hypertension. Hence the objective of this research work is to develop and validate a HPLC method for the simultaneous estimation of Aliskiren and Valsartan in bulk drug and pharmaceutical dosage forms as per ICH guidelines. Various trials were carried out for the optimization of the HPLC method for simultaneous estimation of Aliskiren and Valsartan.

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He is having 14 years of Teaching experience and serving as Principal of V.V. Institute of Pharmaceutical Sciences, Gudlavalleru. He guided Ph.D. and M.Pharm. projects. He conferred with Meritorious University Best Teacher Award from JNTUK, Kakinada. He published 146 papers in various Journals and is Editorial Board Member for 35 reputed journals.