Simvastatin Solid Dispersion Prepared By Microwave Fusion Technique

Simvastatin, a crystalline substance, is a widely used drug for the treatment of hypercholesterolemia. It is a BCS class II drug, having low aqueous solubility (0.76 mg/L) exhibiting poor dissolution pattern and low oral bioavailability (5%). The purpose of this study was to apply the attractive technique of the microwaves fusion for the preparation of solvent-Simvastatin, a crystalline substance, is a widely used drug for the treatment of hypercholesterolemia. It is a BCS class II drug, having low aqueous solubility (0.76 mg/L) exhibiting poor dissolution pattern and low oral bioavailability (5%). The purpose of this study was to apply the attractive technique of the microwaves fusion for the preparation of solvent-free solid dispersions and to enhance the solubility and dissolution rate of simvastatin by a solid dispersion.

Autorentext

Haresh Chaudhary has completed B.pharm and M.pharm from Shri Sarvajanik Pharmacy College,Mehsana and currently working in Formulation Development Department at Cadila Healthcare Ltd, Ahmedabad. He is energetic person with positive attitude toward his goal.