Sjögren's Syndrome

This book first discusses the pathogenesis and etiology of Sjogren's Syndrome. It then addresses diagnosis, classification criterion, and quality of life measurements. Treatment coverage includes conventional therapy, biologics and emerging therapies.

The key knowledge assembled in this book comprises today's most comprehensive resource on Sjögren's syndrome. Sjögren's patients require the care of a wide variety of clinical and surgical specialists to treat their disease and improve their quality of life. This volume presents a broad multi-disciplinary approach, enlisting the expertise of well-respected authors from around the world, covering the specialties of rheumatology, ophthalmology, oral medicine, oral surgery, otolaryngology, hematology, and others.

This practical clinical resource begins with an overview of Sjögren's myths, pearls and tips, information for referring physicians, and diagnostic and classification and criteria. The second section covers pathogenesis, providing the backbone for our understanding current diagnostics and therapeutics. The third section is devoted to clinical manifestations and therapeutic considerations. It covers the entire spectrum of symptoms and treatment, infused with the experience and astute clinical observations of the book's contributors. With system-wide coverage of local and systemic therapy, the book examines current therapy, biologics, and emerging therapeutic targets.

Presenting many international perspectives, this book creates an inter-connective conduit for the global community of Sjögren's patients and physicians.

Integrates the experiences of international experts in the spectrum of involved disciplines Offers a practical approach to the diagnosis and treatment of Sjögren's Syndrome Provides the latest information made possible only by multi-disciplinary communication Presents a global perspective on this prevalent autoimmune disease Includes supplementary material: sn.pub/extras

Inhalt
Introduction.- A Note from Sweden: Recollection of Henrik Sjögren.- Myths, Pearls, and Tips Regarding Sjögren's Syndrome.- Information for Referring Physicians and Patients.- Current Concepts on Classification Criteria and Disease Status Indexes in Sjögren's Syndrome.- Histopathology and Glandular Biopsies in Sjögren's Syndrome.- Imaging Technology in Sjögren's Syndrome: Non-invasive Evaluation of the Salivary Glands.- Genomics and Viruses in Sjögren's Syndrome.- Autoantibodies and Autoantigens in Sjögren's Syndrome.- B-cell Epitopes of Sjögren's Syndrome Related Autoantigens Ro/SSA and La/SSB.- Neurobiology and Hormonal Control of Lacrimal and Salivary Gland Function.- Overview of Management of Dry Eye Associated with Sjögren's Syndrome.- Pathogenesis: Emphasis on Dry Eye and the Role of the Lacrimal Functional Unit in Sjögren's Syndrome.- Oral and Dental Manifestations of Sjögren's Syndrome: Current Approaches to Diagnostics and Therapy.- Emphasis on Dry Mouth and the Role of Salivary Glands.- Otolaryngology Manifestations of Sjögren's Syndrome.- Therapy of Extraglandular Manifestations of Sjögren's Syndrome: Dermatologic, Pulmonary, Gynecologic, Fibromyalgia Manifestations; Considerations for the Surgical SS Patient.- Therapy of Extraglandular Manifestations in the US.- Current Treatment of Extraglandular Manifestations with Disease Modifying and Immunosuppressive Agents.- Lymphoproliferation and Lymphoma in Sjögren's Syndrome.- Fatigue, Dryness, and Quality of Life as Clinical Trial Outcomes in Primary Sjögren's Syndrome.- The Neurological Manifestations of Sjögren's Syndrome.- New Approaches for the Management of Dry Mouth in Sjögren's Syndrome in Japan.- New Approaches for the Management of Dry Eye in Sjögren's Syndrome in Japan.- Sjögren's Syndrome in Australia: Clinical Practice and Research.- Primary Sjögrens Syndrome: Report from India.- Sjögren Syndrome in China.- Sjögren's Syndrome inChina.- Sjögren's Syndrome in Israel: A Scientific Point of View.- Looking Into the FutureThe EULAR Disease Activity Scores: Toward a Consensual Evaluation of Primary Sjögren's Syndrome.- Looking into the Crystal Ball: Initiatives from the Sjögren's Syndrome Foundation that Will Impact Patient Care.- Biological Treatment for Sjögren's Syndrome.- Looking Into the FutureEmerging Therapies Based on Pathogenesis.- Into the Future: Autonomic Neuropathy, MicroRNAs, and Gene Therapy.