Solvent- and Catalyst-Free Organic Synthesis

The toxicity and volatile nature of organic solvents that are widely used in huge amounts for chemical transformations have posed a serious threat to the environment. With the growing awareness in industry and academia for the sustainable development, the development of solvent-free reaction has received tremendous attention in recent years under the title "Green Chemistry". With this context, five different chemical transformations viz., aza-Michael addition of amines to ,beta-unsaturated acids, Knoevenagel condensation of salicylaldehydes and o-aminobenzaldehydes with malononitrile, cascade Knoevenagel-Michael reaction of 4-hydroxy-1-methylquinolin-2(1H)-one, aldehydes and several active methylene compounds, one-pot, three-component reactions for the synthesis of quinazolines and densely functionalized pyrroles have been studied under solvent- and catalyst-free conditions during the present investigation. From the results, it has been observed that, the organic transformations proceed faster and to a high degree of completion when the reaction occurred via homogeneous melt formation. However, the success of the reaction depends on the reactivity of the starting materials.

Autorentext

Subrahmanya I Bhat, received his Ph.D. in Chemistry in 2013 from NITK-Surathkal Mangalore, under the supervision of Dr. Darshak R. Trivedi. He has six years experience in industry and academia. Currently he is working as an Assistant Professor, Chemistry Department, NMAMIT NITTE-574110, India. His research interests include Green organic Synthesis.