Solving Problems in Genetics

This book aims to help undergraduate students in the analysis of genetic problems. Many students have a great deal of difficulty doing genetic analysis, and the book will be useful regardless of which genetics text they use. This work emphasizes solutions, not just answers. The strategy is to provide the student with the essential steps and the reasoning involved in conducting the analysis. Throughout the book, an attempt is made to present a balanced account of genetics. Topics, therefore, center about Mendelian, cytogenetic, molecular, quantitative, and population genetics, with a few more specialized areas.

Inhalt
1 Mendelism.- Basic Probability: Methods for Analyzing Mendelian Genetics.- Forked Line Method.- Mendel's Data.- Crosses Involving Three or More Gene Pairs.- Goodness of Fit Testing.- Subdividing Chi Square.- Gene Interaction.- Distinguishing Among Genetic Ratios.- Double Fertilization in Plants.- Additional Plant Genetics Considerations.- Problems.- Solutions.- Reference.- 2 Sex Determination and Sex Linkage.- General Aspects of Mating Systems.- XX/XY Chromosome System.- Sex Ratios.- Binomial Statistics.- Haploid-Diploid Sex Determination.- Sex Linkage.- Pedigrees.- Partial Sex-Linkage.- Problems.- Solutions.- 3 Chromosomes and Cell Division.- Chromosomes.- The Cell Cycle.- Further Analysis of the Cell Cycle.- Percent Labeled Mitoses Method.- Mitosis.- Meiosis.- Genetic Diversity.- C Values.- Problems.- Solutions.- 4 Linkage, Recombination, and Mapping.- Exceptions to Independent Assortment.- Recombination Values and Genetic Maps.- Three-Point Tests.- Mapping Concepts.- Recombination Calculated with F2 Data.- Haploid Genetics.- Tetrad Analysis.- Tetrad Analysis and Gene Mapping.- Problems.- Solutions.- Reference.- 5 Variations in Chromosome Number and Structure.- Types of Chromosome Variation.- Aneuploidy.- Polyploidy.- Deletions and Duplications.- Inversions.- Translocations.- Other Aberrations.- Problems.- Solutions.- 6 Quantitative Inheritance.- Continuous Variation.- Polygenes.- Estimating Number of Gene Pairs Involved in Quantitative Traits.- Variance.- Broad Sense Heritability.- Narrow Sense Heritability.- Heterosis.- Thresholds.- Mapping Quantitative Traits.- Problems.- Solutions.- Reference.- 7 Population Genetics.- Concept of Gene Pools.- Gene and Genotype Frequencies.- Hardy-Weinberg Principle.- Hardy-Weinberg Equilibrium.- Extensions of Hardy-WeinbergRelationships.- Genetic Drift.- Migration.- Mutation.- Selection.- A Statistical Approach to Change in a Population.- Nonrandom Mating.- Problems.- Solutions.- References.- 8 Gene Concepts.- One-Gene One-Enzyme.- Allelism.- Bacterial Genetics.- Bacteriophages.- Complementation.- Genetic Fine Structure Analysis in Bacteriophages.- Genetic Fine Structure Analysis in Other Organisms.- Problems.- Solutions.- References.- 9 Molecular Basis of Heredity.- Nucleic Acids.- Nearest Neighbor Frequency Analysis.- Central Dogma.- Semiconservative Mode of Replication.- Replication Forks and Okazaki Fragments.- Transcription.- Proteins.- Translation.- Genetic Code.- Regulation.- Operon Systems.- Mutation.- Mutation Detection.- Problems.- Solutions.- References.- 10 Non-Mendelian Inheritance.- Cytoplasmic Inheritance.- Male Sterility in Plants.- Maternal Effects.- Genomic Imprinting.- DNA Trinucleotide Repeats.- Meiotic Drive.- B Chromosomes.- Problems.- Solutions.- 11 Human Genetics.- Mendelian Inheritance in Humans.- Bias of Ascertainment.- Epidemiology and Pedigrees.- Linkage AnalysisClassical Approaches.- Physical Mapping.- Human Genome Project.- Population Genetics.- Testing Inheritance of a Single Allelic Pair in a Population.- Consanguinity.- Methods of Studying the Genetic Basis of Behavior in Humans.- Twin Studies and Concordance.- Problems.- Solutions.- References.- 12 Additional Genetic Analysis Using Statistics.- More Probability.- Permutations and Combinations.- The Binomial Distribution.- Poisson Distribution.- Contingency TablesTest for Independence.- Problems.- Solutions.