Starch Malonate - A New Modified Starch Based Superdisintegrant

Dosage forms are designed in such a way that they can benefit a wide range of patients groups with ease of administration, safety and efficacy. Fast Dissolving Tablets are the most preferred dosage forms nowadays for enhanced quick action, less adverse effects, doctor's choice for all age patients, especially for pediatric, geriatric, and psychotic patients. Superdisintegrants achieve quick disintegration of tablets. Superdisintegrants cause the breakdown of tablets by different mechanisms like swelling, wicking, chemical reaction, repulsive force in between particles, heat due to wetting, enzymatic reactions, and recovery after deformation. But 90% of the superdisintegrants are worked by a mechanism named swelling and wicking. Starch Malonate is a superdisintegrant helps in the faster breakdown of tablets. It helps in the preparation of Fast Dissolving Tablets of poorly soluble drugs and results in faster DT, immediate action and enhanced drug release and bioavailability.

Autorentext
Dr. Santosh Kumar Rada, Assist. Professor, GITAM Institute of Pharmacy, GITAM (Deemed to be University), Visakhapatnam, A.P., India - has 14 years of academic experience in the field of pharmaceutical technology. He was University Topper in his post graduation and published several papers in national and international journals.