Stem Cell Biology in Neoplasms of the Central Nervous System

This volume presents the most current reviews on how cancer stem cells (CSCs) hypothesis dictates that the continued proliferation of a tumor is dependent on a sub-population of self-renewing and asymmetrically dividing neoplastic stem cells that supply a largely differentiated tumor. This volume provides a comprehensive overview of the characteristics of CSCs, their role in central nervous system (CNS) tumors, and the recent CSC-specific treatment modalities being used.

The emerging focus on CSCs in brain tumors represents a paradigm shift in our understanding of the pathogenesis of these neoplasms. Importantly, the realization that a distinct sub-population of cells contributes disproportionately to the growth and sustenance of central nervous system tumors has important implications for the treatment of such tumors. To treat CNS tumors, there is now a growing need to treat CSCs to achieve adequate tumor control.

Discusses varying hypotheses about CSCs to the overall development of CNS tumors Covers basic neuroscience, translational research aspects, and also includes recent SCS-specific treatment and strategies used in clinical research Appeals to cancer researchers, but also those who are involved in neuro-oncology Includes supplementary material: sn.pub/extras

Autorentext

Moneeb Ehtesham, M.D. is a Principal Investigator at the Department of Neurological Oncology at Vanderbilt University Medical Center. His research focuses on cellular therapies on malignant gliomas. He has published over 30 peer-reviewed publications, 3 book chapters, and 38 peer-reviewed abstracts/presentations. He has received over 1260 citations. Dr. Ehtesham has been awarded the Young Investigator Award (2003) by the American Association of Neurological Surgeons & Congress of Neurological Surgeons. He's also been listed in "Who's Who in Stem Cell Research" by DataTrend Publications.

Imad Khan, M.D. is a Research Associate at the Geisel School of Medicine at Dartmouth College. His research focuses on therapies for neurosurgical diseases and disorders. He has published over 30 peer-reviewed publications, 3 book chapters, and over 40 peer-reviewed abstracts/presentations.

Inhalt
Regulation of Subventricular Zone-Derived Cells Migration in the Adult Brain.- The SVC and Its Relationship to Stem Cell Based Neuro-oncogenesis.- Isolation and characterization of stem cells for human central nervous system malignancies.- The role of stem cells in pediatric central nervous system malignancies.- Laboratory models for central nervous system tumor stem cell research.- Radiation Therapy for Glioma Stem Cells.- Chemoresistance and chemotherapy targeting stem-like cells in malignant glioma.- Immunobiology and Immunotherapeutic targeting of glioma stem cells.- Emerging strategies for the treatment of tumor stem cells in central nervous system malignancies.