Stem Cells and Cancer Stem Cells, Volume 7

Covering a full range of stem cells with therapeutic applications, this volume explains the regenerative potential of stem cells and their mesenchymal progeny, reviewing clinical uses of the latter in treating cancer, diabetes and neurodegenerative disorders.

The seventh in Springer's landmark series of edited volumes on one of the highest-profile subjects in contemporary medicine and scientific endeavour, this volume sets out to cover a staggering range of research into the medical applications of stem cell research. While stem cells are the very stuff of life for multicellular organisms, including us humans, the cancer stem cell is a morbid entity with a robust resistance to therapies including conventional chemotherapy. This authoritative publication explains the regenerative potential of stem cells and their mesenchymal progeny, reviewing clinical applications of the latter in the treatment of cancer, diabetes and neurodegenerative pathologies. It covers the entire range of stem cells with known potential for therapeutic use, from human embryonic to germ cell-derived pluripotent stem cells and hematopoietic stem cells. The chapters also deal with the role of TGF-beta in propagating human embryonic stem cells, and in facilitating their differentiation. Featuring discussions of molecular signaling pathways that modulate mesenchymal stem cell self-renewal and much more, this book is certain to have broad appeal among academicians and physicians alike.

Regenerative medicine Cell or tissue transplantation Disease and injury therapy Color figures and tables Extensive references

Klappentext

This seventh volume in the Springer's landmark series of edited books discusses one of the most important subjects in contemporary medicine and scientific endeavors. The volume presents a staggering range of research into medical applications of stem cells and cancer stem cells. While stem cells are essential for normal life of multicellular organisms, including humans, cancer stem cells are a morbid entity having a robust resistance to therapies including conventional chemotherapy and radiotherapy.

This authoritative publication explains the regenerative potential of stem cells and their mesenchymal progeny, reviewing clinical applications of the latter in the treatment of cancer, diabetes and neurodegenerative pathologies. It covers the entire range of stem cells with known potential for therapeutic use, from human embryonic to germ cell-derived pluripotent stem cells and hematopoietic stem cells. The chapters also deal with the role of TGF-beta in propagating human embryonic stem cells, and in facilitating their differentiation. Featuring discussions of molecular signaling pathways that modulate mesenchymal stem cell self-renewal and much more, this book is certain to have broad appeal among academicians and physicians alike.

Inhalt

Preface. I. Regenerative medicine.-1Mesenchymal stem cell expansion for therapeutic application.-6 Mobilization of pluripotent stem cells in patients with myocardial ischemia: from the bench to bedside.-2 Role of induced pluripotent stem cells in regenerative medicine.-3 Sulforaphane as new therapeutic agent for targeting of cancer stem cells with focus to prostate and pancreatic cancer.-4 Technology platforms for heart regenerative therapy using pluripotent stem cells.-5 Myocardial regeneration of adipose tissue-derived stem cells: differentiation, paracrine, fusion mechanisms.-7 Mammary regeneration using embryonic stem cell engraftment.-8 Recovery of the bone marrow in lethally irradiated host: role of hyper-activated stem cell factor receptor.-9 Potential of bone marrow-derived stem cells in treatment of genetic diseases of the liver.-10 Propagation of human bone marrow stem cells for craniofacial applications.-11 Maintenance of pluripotency in mouse stem cells: use of hyaluronan in the long-term culture.-12 Initiation of soft tissue sarcomas: muscle stem/progenitor cells as targets.-13 Mesenchymal stem cells: complex players in lung repair & injury.II. Tissue engineering.-14 Human embryonic stem cell-derived mesodermal progenitors for bone engineering.-15 The role of chondrogenic factors in differentiation of bone marrow stromal cells to the cartilage lineage.-16 Chondrogenic differentation of human mesenchymal stem cells: effect of electromagnetic fields.-17 Differentiation of human embryonic stem cells and human induced pluripotent stem cells into retinal pigment epithelium.-18 Stem cells and stress injury: role of arginine decarboxylase.III. Transplantation.-19 Treatment of cerebellar ataxias: transplantation of human embryonic stem cells.-20 A new concept of stem cell disorders, and the rationale for transplantation ofnormal stem cells.-21 Manipulation, guidance and tracking of mesenchymal stem cells for regenerative medicine and transplantation: the role of magnetic nanoparticles.IV. Neural applications.-22 Differentiation of human embryonic stem cells into neural lineage cells.-23 Use of recombinant viruses to manipulate neural stem cell gene expression in the mouse brain.-24 Accelerated neural differentiation of human induced pluripotent stem cells using chlorate treatment.-25 Application of epiblast/germ line-derived very small embryonic-like stem cells for neurogenesis. Index.