Stereoselective Total Synthesis of the Natural Oxylipin

In this context, we have developed a simple and straight forward synthesis of the natural oxylipin, (6R,7E,9R,10S)-6,9,10-trihydroxyoctadeca-7-enoic acid. The starting materials were nonanal and 1,6-hexanediol and the key steps were Sharpless kinetic resolution, asymmetric epoxidation and olefin cross metathesis. The reaction steps involved in the present synthesis are lesser compared to those required for the previous one.

Autorentext
Dr. N. Salvanna, Assistant Professor, Department of Chemistry, University Post Graduate College (OU), Narsapur , Medak-502313.Dr. G. Madhu, Assistant Professor, Department of Chemistry, Nizam College, OU, Hyd.Dr. K. Santosh Kumar, Assistant Professor, Department of Chemistry, Geethanjali College of Engineering and Technology, Cheeryal, Medchal.