Stress Resilience

Stress Resilience: Molecular and Behavioral Aspects presents the first reference available on the full-breadth of cutting-edge research being carried out in this field. It includes a wide range of basic molecular knowledge on the potential associations between resilience phenomenon and biochemical balance, but also focuses on the molecular and cellular mechanisms underlying stress resilience. World-renowned experts provide chapters that cover everything from the neural circuits of resilience, the effects of early-life adversity, and the transgenerational inheritance of resilience.

This unique and timely book will be a go-to resource for neuroscientists and biological psychiatrists who want to improve their understanding of the consequences of stress and on how some people are able to avoid it.

Autorentext

Prof. Alon Chen is a world leading neuroscientist and the 11th President of the Weizmann Institute of Science. Prof. Chen's research into the neurobiology and neuroendocrinology of stress focuses on the genomic, epigenomic and cellular mechanisms by which the brain regulates the response to stressful challenges and how this response may be linked to a number of psychiatric and physiological disorders. The long-term goal of his research is to elucidate the genetic, epigenetic, and cellular pathways and mechanisms by which stressors are perceived, processed, and converted into neuroendocrine and behavioral responses under healthy and pathological conditions.

His lab has made significant discoveries in the field, revealing fundamental genetic, epigenetic, and cellular aspects of the stress response in both animals and humans, including actions that link specific stress-related genes, epigenetic mechanisms and brain circuits to anxiety disorders, depression, eating disorders and metabolic syndrome.

Prof. Chen was the Head of the Department of Brain Sciences at the Weizmann Institute of Science, and a Director and Scientific Member of the Max Planck Institute of Psychiatry, Munich, Germany.

Klappentext

Stress Resilience: Molecular and Behavioral Aspects presents the first reference available on the full-breadth of cutting-edge research being carried out in this field. It includes a wide range of basic molecular knowledge on the potential associations between resilience phenomenon and biochemical balance, but also focuses on the molecular and cellular mechanisms underlying stress resilience. World-renowned experts provide chapters that cover everything from the neural circuits of resilience, the effects of early-life adversity, and the transgenerational inheritance of resilience.

This unique and timely book will be a go-to resource for neuroscientists and biological psychiatrists who want to improve their understanding of the consequences of stress and on how some people are able to avoid it.

Inhalt

1. A life-course, epigenetic perspective on resilience in brain and body
   
   2. Cognitive and behavioral components of resilience to stress
   3. Resilience as a process instead of a trait
   4. The brain mineralocorticoid receptor: A resilience factor for psychopathology?
   5. GABAB receptors and stress resilience: A tale of two isoforms
   6. Sex differences in the programming of stress resilience
   7. Active resilience in response to traumatic stress
   8. Rhythms of stress resilience
   9. Mitochondrial function and stress resilience
   10. Understanding resilience: Biological approaches in at-risk populations
   11. Stress resilience as a consequence of early-life adversity
   12. Mechanisms by which early-life experiences promote enduring stress resilience or vulnerability
   13. Child abuse and neglect: Stress responsivity and resilience
   14. How genes and environment interact to shape risk and resilience to stress-related psychiatric disorders
   15. Molecular characterization of the resilient brain: Transcriptional and epigenetic mechanisms
   16. The role of the CRF-Urocortin system in stress resilience
   17. Intergenerational transmission of stress vulnerability and resilience
   18. stress and its effects across generations
   19. Corticolimbic stress-regulatory circuits, hypothalamo-pituitary-adrenocortical adaptation and resilience
   20. Biomarkers of resilience and susceptibility in rodent models of stress
   21. Maladaptive learning and the amygdala - prefrontal circuit
   22. Endocannabinoid signaling and stress resilience