Studies on Chromene Derivatives

Chromans, chromenes and Dihydrocoumarins, are important classes of benzopyran derivatives found in many natural products and synthetic molecules exhibiting unique biological and pharmacological activities. For instances, splitomicin and its analogues are known to be Sir2 inhibitors, vitamin E and trolox are well-known antioxidants and -transtocotrienoloic acid has antibacterial activity. Rhododaurichromanic acid-A shows potent anti-HIV activity and siccanin possesses strong antifungal activity. In addition to this 2-Substituted chromans (benzopyrans) are widely distributed in nature and many show signi cant biological activity. Chromans are also valued as targets in their own right and several biologically active synthetic chromans have been reported. Owing to the importance of the benzopyran framework, its construction has attracted considerable attention of researchers. This book reports the strategic design, synthesis, characterization and biological evaluation of chromene derivatives.

Autorentext

The author has completed his Masters & Doctorate in Chemistry from Saurashtra University. Currently he is working with Forensic Science Laboratory-Rajkot, Gujarat-India. He has also worked with R & D division of Zydus Cadila and Cadila Pharma. He has published the International Patent (In WIPO,EPO&US) and 6 Research Articles in Reputed Journals.