Studies on diagnostic & prognostic markers of ovine pregnancy toxemia

This study was conducted on ewes with pregnancy toxemia (PT) with an attempt to evaluate metabolic and oxidative profile in subclinical and clinical ovine pregnancy toxemia and to determine their association with diagnosis and prognosis of the disease. A total of, 20 ewes having beta-hydroxy butyric acid (beta-HBA) >2.5mmol/l and proven clinical sings of PT, categorized as clinical PT (CPT), 12 ewes having beta-HBA 0.8-2.5mmol/l and no clinical signs of PT, categorized at subclinical PT (SPT) and 10 ewes having beta-HBA 0.8mmol/l, categorized as healthy control (CON) were enrolled. Among 20 CPT ewes, 11 had negative outcomes (non-survivors), six ewes had positive outcomes (survivors) and three were lost during follow-up. A significant increase in non-esterified fatty acid, beta-HBA, triglycerides, gamma-glutamyl transferase, lactate dehydrogenase, malondialdehyde levels and significant decrease in fructosamine was observed in CPT and SPT compared to CON. Significant increase in cholesterol, aspartate amino transferase, creatinine kinase, and significant decrease in albumin, potassium, calcium, superoxide dismutase and catalase was observed in CPT only.

Autorentext

Trabalho na Faculdade de Ciências Veterinárias da Universidade de Ciência e Tecnologia Agrícola Sher-e-Kashmir; Kashmir e tenho 8 anos de experiência como Professor Assistente em Medicina Veterinária. Tenho sido Professor Assistente visitante na Universidade de Toledo, Ohio, EUA, onde tenho trabalhado em doenças neurodegenerativas.