Studies on the super-disintegrants in novel oral solid dosage forms

This Book is about fast-dissolving tablets (FDTs) are "they are uncoated tablets that are supposed to be placed in the mouth and dispersed quickly before being swallowed" within minutes. This study aimed to formulate and evaluate a combination of ketorolac and rizatriptan as orally fast-dissolving tablets using the most common and easiest method to treat migraine attacks with or without aura. To examine how different diluents and superdisintegrants affect the wetting time, water absorption ratio, disintegration time, and dissolution time of combination drugs (ketorolac and rizatriptan) as oral fast dissolving tablets made using the direct compression technique. Pre-formulation experiments were carried out to rule out any physicochemical interactions between the two medications (ketorolac and rizatriptan) and between each drug and its excipients. Four different formulations of fast-dissolving tablets with different types and ratios of diluents and super disintegrants were created using the direct compression technique in order to improve the formulation-organoleptic characteristics, weight variance, thickness, friability, hardness, disintegration rate.

Autorentext

Ich bin der Pharmazeut Rawand Sirwan. Ich habe einen Bachelor-Abschluss in Pharmazie und einen Master-Abschluss in Pharmazie (Pharmazeutische Technologie), und ich bin Akademiker, zertifizierter Ausbilder und Forscher.

Klappentext

This Book is about fast-dissolving tablets (FDTs) are "they are uncoated tablets that are supposed to be placed in the mouth and dispersed quickly before being swallowed" within minutes. This study aimed to formulate and evaluate a combination of ketorolac and rizatriptan as orally fast-dissolving tablets using the most common and easiest method to treat migraine attacks with or without aura. To examine how different diluents and superdisintegrants affect the wetting time, water absorption ratio, disintegration time, and dissolution time of combination drugs (ketorolac and rizatriptan) as oral fast dissolving tablets made using the direct compression technique. Pre-formulation experiments were carried out to rule out any physicochemical interactions between the two medications (ketorolac and rizatriptan) and between each drug and its excipients. Four different formulations of fast-dissolving tablets with different types and ratios of diluents and super disintegrants were created using the direct compression technique in order to improve the formulation organoleptic characteristics, weight variance, thickness, friability, hardness, disintegration rate.