Studies Towards the Synthesis of ( )-Ebelactone-A and ( )-Maurenone
Details
This monograph features the studies directed towards the total synthesis of architecturally and biologically interesting polypropionate natural products (-)-Ebelactone-A and (-)-Maurenone utilizing desymmetrization as a key strategy. ( )-Ebelactone A, show structural characteristics in common with macrolide antibiotics. Ebelactones act as potent inhibitors of esterase s, lipases and N-formylmethionine amino peptidases, and they have shown to produce enhance immune responses. They are also reported to inhibit cutinases produced by fungal pathogens. Novel biological activity combined with unique and challenging structure of Ebelactone, made this compound an exciting target for the total synthesis. Secondly, this book described an efficient synthetic protocol for polypropionate natural product (-)-Maurenone, which was isolated by Faulkner et al. in 1986 from specimens of the pulmonate mollusc Siphonaria maura. This monograph is unique in dealing with many interesting synthetic protocols including full experimental procedures, analytical data for all synthetic materials and complete reference sections. This monograph can be served as a good hand book for synthetic organic chemists.
Autorentext
Ravindar Kontham was born in Ashalapally-Warangal, India in 1978. He completed BSc, PhD from Kakatiya University & M.Sc from Osmania University, India. Completed his PhD under the guidance of Dr. J. S. Yadav, Director, CSIR-IICT, Hyderabad, India. Currently he is a post-doctoral fellow with Prof. Pierre Deslongchamps, University Laval, QC, Canada.
Weitere Informationen
- Allgemeine Informationen
- GTIN 09783848449583
- Sprache Englisch
- Auflage Aufl.
- Genre Chemie
- Größe H220mm x B220mm
- Jahr 2012
- EAN 9783848449583
- Format Kartonierter Einband (Kt)
- ISBN 978-3-8484-4958-3
- Titel Studies Towards the Synthesis of ( )-Ebelactone-A and ( )-Maurenone
- Autor Ravindar Kontham , Jhillu Singh Yadav
- Untertitel Studies Directed Towards the Total Synthesis of Polypropionate Natural Products ( )-Ebelactone-A and ( )-Maurenone
- Herausgeber LAP Lambert Academic Publishing
- Anzahl Seiten 164