Study Of Diclofenac Sodium 12H From Acrylic Polymer Coating Materials

The present study is to investigate the effect of Ammonio Methacrylate Copolymer Type B (Eudragit RS 30 D) on the release kinetics study of diclofenac sodium form coated pellets. Eudragit RS 30 D and xanthan gum was added into the formulation at 5:1 ratio. Different percent of this polymeric combination was loaded on to the drug-loaded pellets. It was found that the cumulative % release of drug decreased with the increase of polymer load in all cases. Better sustaining effect was found from Eudragit RS 30 D and xanthan gum combinations. Drug was released linearly along with time throughout the whole dissolution process in phosphate buffer (pH 6.8) and it was also revealed that, in all cases the release of diclofenac sodium followed mixed release kinetics but zero order release kinetics predominates.

Autorentext

Passed M. Pharm from Department of Pharmaceutical Technology,University of Dhaka,Bangladesh and currently employed as a Lecturer in the Department of Pharmacy, Stamford University,Dhaka,Bangladesh.