Synthesis And Molecular Docking of Ether Mitsunobu reaction

The Mitsunobu reaction is very important reaction for the synthesis of ether from phenol and alcohol. The [7-methoxy-2-(4-methoxyphenyl)-1-benzofuran-5-yl]methanol (2) was synthesised from vanillin by using series of known reactions such as Mannich reaction, acetylation, hydrolysis, Wittig raction, hydrobation. This methanol benzofuran derivative (2) condensed with 4-fluorophenol by using DEAD in THF. The final product 5-[(4-fluorophenoxy)methyl]-7-methoxy-2-(4-methoxyphenyl)-1-benzofuran (3) was characterised by using IR, NMR and mass spectra and study their biological activity by molecular docking using molecular docking software Glide. The activity of ether (3) was compared to their amine analogue.

Autorentext

Dr. Bapu R Thorat Ph.D. in chemistry published more than 88 research papers, and 18 books, has 2 patents in his credits.Dr. Rupali Manikrao Biradar - Ph.D. in Botany has 15 years of research experience. Expert in chromatography and applied science.Megha Rai has published 72 research papers and completed one major research project at UGC.