Synthesis, Formulation and Evaluation of Some Selected Microspheres

Excellent achievements have been made in management/treatment of disease conditions through invention of newer drug entities or therapies over the past two decades. Diabetes is growing in today's world at a very high speed and indeed Oral Hypoglycaemic agents are one of the major breakthroughs in this context. But because of short plasma half life & repetitive dosing, this treatment becomes inconvenient and problematic. In the present work, efforts were made to design a biodegradable micro-particulate drug delivery system which promises in maintaining the plasma drug level without repetitive dosing. The primary objective of the present research work was to prepare a long circulating drug delivery system of oral hypoglycaemic drugs for long term management of Type-II diabetes mellitus with improved efficacy by microsphere for overcoming the problems of drug delivery through conventional dosage forms. The proposed micro-particulate drug delivery system of biodegradable polymers was capable to maintain the blood sugar level for few days, without the need for frequent dosing; decreased side effects as in case of conventional drug delivery and hence increased patient compliance.

Autorentext

Dr. Engla is presently working at School of Pharmacy, Devi Ahilya University, Indore, INDIA; He is having more than 15 years of experience in the field of pharmaceutical academia and research. Dr. Engla is alumnus of DOPS, Sagar, India and the field of his academics and research includes Plant Biotechnology, Drug Delivery and Environmental Science