Synthesis of Bioactive Heterocycles using 3-Acetyl Quinolines

Quinoline heterocycles found to have diverse biological activities and 3-functionalised quinolines are important intermediates for the synthesis of various quinoline derivatives. 3-acetyl-4-hydroxy-quinolin-2(1H)-one and 6-chloro-3-acetyl-4-phenyl-2-methyl quinoline were chosen as intermediates for the synthesis of some novel quinoline derivatives. In particular, only a few methods are available for the synthesis of 3-acetyl-4-hydroxy-quinolin-2(1H)-one, which involve either two step or multistep reaction protocols. In the present work, a rapid, efficient and one pot procedure for the synthesis of 3-acetyl-4-hydroxy-quinolin-2(1H)-ones has been developed both by conventional and microwave assisted synthesis. The 3-acetyl quinolines were converted into chalcones which in turn converted to quinoline-3-yl pyrazolines and quinoline-3-yl isoxazolines and a few into 3-(2, 4-substitutedstyryl)isoxazolo[4,5-c]quinolin-4(5H)-ones. These compounds were explored for their anti-microbial and cyctotoxicity studies.

Autorentext

Associate Professor in Organic Chemistry Division at VIT University, Vellore completed Ph.D at Gandhigram University, Dindigul in Nitrogen Heterocycles. Currently focusing on the synthesis of various heterocycles and exploring their applications in medicinal field; published more than 130 articles in various international journals.